2003. 02 Ph.D. College of Pharmacy, Sungkyunkwan University
1994. 02 M.S. College of Pharmacy, Sungkyunkwan University
1992. 02 B.S. College of Pharmacy, Sungkyunk

Major Careers
2021.04-Present Associate Professor, College of Pharmacy, JeJu University
2016.07-2021.03 Program Director of Bio, Korea Evaluation Institute of Industrial Technology
2007.11 -2016.03 Head of New Medicines Discovery Center, Life Science Research Institute, Daewoong Pharmaceutical Co. Ltd.
2003.03 - 2007.11 Postdoctoral Research Fellow, The University of North Carolina at Charlotte, NC, USA
2000.02 - 2002.03 Pharmacists, Department of Pharmacy, Kangnam General Hospital Public Corporation
1994.01 - 2000.01 Senior Scientist, Drug Discovery Department, Yuhan Pharmaceutical Research Center

1. HB Kim, N Meghan, M Park, SH Lee, SR Lee, YJ Cho, YH Doh, KH Choi. Electrohydrodynamically Atomized pH-Responsive PLGA/ZnO Quantum Dots for Local Delivery in Lung Cancer. Macromol. Res, 2020.

2. N Meghan, KH Kim, SH Kim, SH Lee, KH Choi. Evaluation and live monitoring of pH-responsive HSA-ZnO nanoparticles using a lung-on-a-chip modelr. Arch Pharm Res. 43:503-513, 2020.

3. ARC Salih, HMU Farooqi, YS Kim, SH Lee, KH Choi. Impact of serum concentration in cell culture media on tight junction proteins within a multiorgan microphysiological system. Microelectronic Eng. 232:1-12, 2020.

4. M Ali, YS KIM, MAU Khalid, AM Soomro, JW Lee, JH Lim, KH Choi, SH Lee.
On-chip real-time detection and quantification of reactive oxygen species in MCF-7 cells through an in-house built fluorescence microscope. Microelectronic Eng. 233:1-13, 2020.

5. F Jabbar, AM Soomro, JW Lee, M Ali, YS Kim, SH Lee, KH Choi. Robust Fluidic Biocompatible Strain Sensor Based on PEDOT:PSS/CNT Composite for Human-wearable and High-end Robotic Applications. Sensor and Materials 32:4077-4093, 2020.

6. JB Lee, B Shin, SH Lee, BY Lee, TH Kim, MG Kim, SD Yoo. Exposure assessment of epidermal growth factor to various tissues in mice after intravenous and subcutaneous administration. J Pharm Pharmacol. 67:1519-1527, 2015.

7. TH Kim, SH LEE, SM LEE. Role of kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction. FEBS J. 278:2307-2317, 2011.

8. LO Byerley, SH Lee, S Redmann, C Culberson, MG Clemens, MO Lively. Evidence for a novel serum factor distinct from zinc alpha-2 glycoprotein that promotes body fat loss early in the development of cachexia. Nutrition and Cancer. 62:484-494, 2010.

9. SH Lee, Clemens MG, SM Lee. Role of Kupffer cells in vascular stress genes during trauma and sepsis. J Surg Res. 158:104-111, 2010.

10. W Kwok, SH Lee, K Korneszczuk, C Culberson, and MG Clemens. Caveolin-1 mediates endotoxin inhibition of endothelin-1-induced endothelial nitric oxide synthase activity in liver sinusoidal endothelial cells. Am J Physiol Gastrointest Liver Physiol. 297:G930-939, 2009.

11. SH Lee, C Culberson, K Korneszczuk, MG Clemens. Differential mechanisms of hepatic vascular dysregulation with mild vs moderate ischemia / reperfusion. Am J Physiol Gastrointest Liver Physiol, 294:G1219-1226, 2008.

12. S Jain, SH Lee, C Culberson, K Korneszczuk, MG Clemens, C Lee. Improved preservation of warm ischemic livers by hypothermic machine perfusion with supplemented University of Wisconsin solution. J Invest Surg, 21:83-91, 2008.

13. SH Lee, RN Coger, MG Clemens. Antioxidant Functionality in Hepatocytes using the enhanced collagen extracellular matrix under different oxygen tensions. Tissue Eng, 12:2825-2834, 2006.

14. SH Lee, SM Lee. Suppression of hepatic cytochrome P450-mediated drug metabolism during the late stage of sepsis in rats. Shock, 23:144-149, 2005.

15. HA Eum, SH Lee, SM Lee. Trolox C ameliorates hepatic drug metabolizing dysfunction after ischemia/reperfusion. Arch Pharm Res 25:940-945, 2002.

16. SH Lee, WY Oh, JC Kim, SS Jew, HY Park, KS Ham, JS Cho, SM Lee. Single oral toxicity (R)-JG-381 in Sprague-Dawley rats. J Appl Pharmacol 10:7-11, 2002.

17. WY Oh, SH Lee, JH Kim, SS Jew, HY Park, KS Ham, JS Cho, SM Lee. Single oral toxicity of JG-381 in rats. J Appl Pharmacol 9:231-235, 2001.

18. WY Oh, SH Lee, SS Jew, HY Park, KS Ham, JS Cho, SM Lee. General pharmacology of (R)-JG-381, a new antidiabetic agent. J Appl Pharmacol 9:63-68, 2001.

19. YG Lee, SH Lee, SM Lee. Role of Kupffer cells in cold/warm ischemia-reperfusion injury of rat liver. Arch Pharm Res 23: 620-625, 2000.

20. KW Yoon, SH Lee, SM Lee. Effects of vitamins C and E on hepatic drug metabolizing function in hypoxia/reoxygenation. Yakhak Hoeji 44:237-244, 2000.

21. KW Yoon, SH Lee, SM Lee. Hepatic injury studied in two different hypoxic models. J Appl Pharmacol 8:119-124, 2000.

22. SH Lee, BK Lee, SM Lee, JD Park, TS Cho. Inhibitory effects of devazepide on the pancreaticobiliary secretion of ginseng saponin in rats. J Appl Pharmacol 7:138-144, 1999.

23. MJ Park, DS Park, SH Lee, SM Lee, TS Cho. Lipid peroxidation of hepatic drug-metabolizing system in hepatic ischemia and reperfusion. J Appl Pharmacol 2:141-148, 1994.

2012.08 Ph.D. College of Pharmacy, Pusan National University
2009.08 M.S. College of Pharmacy, Pusan National University
2007.02 B.S. College of Pharmacy, Pusan National University

1. B Avula, S Sagi, MH Masoodi, J-Y Bae, AF Wali, IK Khan (2020) Quantification and characterization of phenolic compounds from northern Indian propolis extracts and dietary supplements. Journal of AOAC International ISSN: 1060-3271 (IF: 1.201) accepted
2. J-Y Bae, B Avula, Y-H Wang, M Wang, F Zulfiqar, Z Ali, AM Viljeon, IA Khan (2020) Development and Validation of a UHPLC-PDA-MS Method for the Quantitative Analysis of Anthraquinones in Bulbine natalensis Extracts and Dietary Supplements. Planta Medica 86(02) 144-150 https://doi.org/10.1055/a-37-4051. ISSN: 0032-0943 (IF: 2.746) Epub 25 Nov 2019; Jan 2020
3. J-Y Bae, B Avula, J Zhao, V Raman, Y-H Wang, M Wang, F Zulfiqar, W Feng, JH Park, N Abe, Z Ali, IA Khan (2020) Analysis of Prenylflavonoids from Aerial Parts of Epimedium grandiflorum and Dietary Supplements using HPTLC, UHPLC-PDA and UHPLC-QToF along with Chemometric Tools to Differentiate Epimedium Species. Journal of Pharmaceutical and Biomedical Analysis 177: 112843. https://doi.org/10.1016/j.jpba.2019.112843. ISSN: 0731-7085 (IF: 2.983) Epub 28 Aug 2019; 05 Jan 2020
4. C Crawford, Y-H Wang, B Avula, J-Y Bae, IA Khan, PA Deuster (2020) The scoop on brain health dietary supplement products containing huperzine A, Clinical Toxicology, products containing huperzine A, Clinical Toxicology, https://doi.org/10.1080/15563650.2020.1713337 ISSN: 1556-3650 (Print) Published online: 28 Jan 2020 (IF: 4.398)
5. J-Y Bae, Z Ali, Y-H wang, AG Chittiboyina, AA Zaki, AM Viljeon, IA Khan (2019) Anthraquinone-Based Specialized Metabolites from Rhizomes of Bulbine natalensis. Journal of Natural Products 82: 1893-1901. https://doi.org/10.1021/acs.jnatprod.9b00187 ISSN: 0163-3864 (IF: 4.257) JCR 7.02% 09 Jul 2019
6. B Avula, J-Y Bae, AG Chittiboyina, Y-H Wang, M Wang, IA Khan (2019) Liquid chromatography-quadrupole time of flight mass spectrometric method for targeted analysis of 111 nitrogen-based compounds in weight loss and ergogenic supplements. Journal of Pharmaceutical and Biomedical Analysis 174: 305-323. https://doi.org/10.1016/j.jpba.2019.05.066 (co-first author) ISSN: 0731-7085 (IF: 2.983) 10 Sep 2019
7. AAK Khalil, WS Park, JH Lee, H-J Kim, K-M Akter, Y-M Goo, J-Y Bae, M-S Chun, J-H Kim, M-J Ahn (2019) A new anti-Helicobacter pylori juglone from Reynoutria japonica. Archives of pharmacal research 42(6): 505-511. https://doi.org/10.1007/s12272-019-01160-x ISSN: 0253-6269 (IF: 2.458) June 2019
8. BJ Gurley, IR Miousse, I Nookaew, LE Ewing, CM Skinner, P Jenjaroenpun, T Wongsurawat, SK McGill, B Avula, J-Y Bae, MR McGill, D Ussery, IA Khan, I Koturbash (2019) Decaffeinated Green Tea Extract Does not Elicit Hepatotoxic Effects and modulates the Gut Microbiome in Lean B6C3F1 Mice, Nutrients 11(4): 776. https://doi.org/10.3390/nu11040776 ISSN: 2072-6643 (IF: 4.171) 03 Apr 2019
9. MH Haron, B Avula, Q Shi, X-C Li, MK Ashfaq, J-Y Bae, S Guan, M Hinchee, IA Khan, SI Khan (2019) Quantitative Determination and Pharmacokinetic Study of Fusaricidin A in Mice Plasma and Tissues using UHPLC-Tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis 170: 187-192. https://doi.org/10.1016/j.jpba.2019.03.042 ISSN: 0731-7085 (IF: 2.983) 5 June 2019
10. B Avula, AG Chittiboyina, J-Y Bae, S Haider, Y-H Wang, M Wang, J Zhao, PA Deuster, IA Khan (2019) The power of hyphenated chromatography―Time of flight mass spectrometry for unequivocal identification of spirostanes in bodybuilding dietary supplements. Journal of Pharmaceutical and Biomedical Analysis 167: 74-82. https://doi.org/10.1016/j.jpba.2018.12.045 ISSN: 0731-7085 (IF: 2.983) 15 Apr 2019
11. B Avula, J-Y Bae, V Raman, OI Fantoukh, YH Wang, AG Osman, M Wang, Z Ali, IA Khan (2019) Quantification of Phenolic Compounds from Fadogia agrestis and Dietary Supplements using UHPLC-PDA-MS. Planta Medica 85(2):145-153. https://doi.org/10.1055/a-0715-1801 (co-first author) ISSN: 0032-0943 (IF: 2.746) Jan 2019
12. V Raman, JM Budel, J Zhao, J-Y Bae, B Avula, AG Osman, Z Ali, IA Khan (2018) Microscopic characterization and HPTLC of the leaves, stems and roots of Fadogia agrestis ？ an African folk medicinal plant. Revista Brasileira de Farmacognosia 28(6): 631-639. https://doi.org/10.1016/j.bjp.2018.07.006 ISSN: 0102-695X (IF: 1.754) Dec 2018
13. B Avula, J-Y Bae, T Majrashi, T-Y Wu, Y-H Wang, M Wang, Z Ali, Y-C Wu, IA Khan (2018) Targeted and non-targeted analysis of annonaceous alkaloids and acetogenins from Asimina and Annona species using UHPLC-QToF-MS. Journal of Pharmaceutical and Biomedical Analysis 159: 548-566. https://doi.org/10.1016/j.jpba.2018.07.030 (co-first author) ISSN: 0731-7085 (IF: 2.983) 10 Sep 2018
14. B Avula, BL Tekwani, ND Chaurasiya, P Fasinu, NP Dhammika Nanayakkara, HMT Bhandara Herath, YH Wang, JY Bae, SI Khan, MA Elsohly, JD McChesney, PA Zimmerman, IA Khan, LA Walker (2018) Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry. Malaria Journal 17(1):294 https://doi.org/10.1186/s12936-018-2433-z ISSN: 1475-2875 (IF: 2.798) 13 Aug 2018
15. J Ren, T Zeng, Z Ali, M Wang, J-Y Bae, AG Chittiboyina, W Wang, S Li, IA Khan (2017) Cyclopiperettine, a new amide from Piper nigrum. Natural product communications 12(12):1855-1856. ISSN: 1934-578X (IF: 0.554) 01 Dec 2017 https://doi.org/10.1177/1934578X1701201210
16. HJ Kim, WS Park, J-Y Bae, SY Kang, MH Yang, SH Lee, H-S Lee, S-S Kwak, M-J Ahn (2015) Variations in the carotenoid and anthocyanin contents of Korean cultural varieties and home-processed sweet potatoes. Journal of Food Composition and Analysis 41: 188-193. ISSN: 0889-1575 (IF: 2.994) Aug 2015 https://doi.org/10.1016/j.jfca.2015.01.012
17. J-Y Bae, CY Kim, HJ Kim, JH Park, M-J Ahn (2015) Differences in the chemical profiles and biological activities of Paeonia lactiflora and Paeonia obovata. Journal of Medicinal Food 18(2): 224-232. ISSN: 1096-620X https://doi.org/10.1089/jmf.2014.3144 (IF: 2.020) Feb 2015
18. WS Park, J-Y Bae, HJ Kim, MG Kim, W-K Lee, H-L Kang, S-C Baik, KM Lim, MK Lee, M-J Ahn (2015) Anti-Helicobacter pylori compounds from Maackia amurensis. Natural Product Sciences 21(1): 49-53. ISSN: 1226-3907 31 Mar 2015 http://www.piboc.dvo.ru/tmp/15_21_49.pdf
19. S-C Park, Y-H Kim, SH Kim, YJ Jeong, CY Kim, JS Lee, J-Y Bae, M-J Ahn, SC Jeong, H-S Lee, S-S Kwak (2015) Overexpression of the IbMYB1 gene in a yellow-fleshed sweetpotato cultivar produces a dual-pigmented transgenic sweetpotato with improved antioxidant activity. Physiologia Plantarum 153(4): 525-537. ISSN: 0031-9317 https://doi.org/10.1111/ppl.12281 SCIE (IF: 3) 16 Mar 2015
20. SH Kim, JC Jeong, SY Park, J-Y Bae, M-J Ahn, H-S Lee, S-S Kwak (2014) Down-regulation of sweetpotato lycopene β-cyclase gene enhances tolerance to abiotic stress in transgenic calli. Molecular biology reports 41(12):8137-8148. ISSN: 0301-4851 (IF: 2.107) https://doi.org/10.1007/s11033-014-3714-4 Dec 2014
21. EJ Jeong, J-Y Bae, J-R Rho, YC Kim, M-J Ahn, SH Sung (2014) Anti-inflammatory triterpenes from Euonymus alatus leaves and twigs on lipopolysaccharide-activated RAW 264.7 macrophage cells. Bulletin of the Korean Chemical Society 35:2945-2949. ISSN: 1229-5949 (IF:0.602) http://dx.doi.org/10.5012/bkcs.2014.35.10.2945 20 Oct 2014
22. MK Shim, J-Y Bae, YJ Lee, M-J Ahn (2014) Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors. Phytomedicine 21: 602-606. (co-first author) ISSN: 0944-7113 https://doi.org/10.1016/j.phymed.2013.10.022 (IF: 4.18) JCR 3.7% 15 Apr 2014
23. KD Yoon, S-N Kang, J-Y Bae, H-S Lee, S-S Kwak, IS Jang, I-S Kim, SH Lee, JM Bae, SW Lee, M-J Ahn (2013) Enhanced antioxidant and protective activities on retinal ganglion cells of carotenoids-overexpressing transgenic carrot. Current Drug Targets 14(9): 999-1005. ISSN: 1389-4501/1873-5592 (online) (IF: 2.642) https://doi.org/10.2174/1389450111314090008 Aug 2013
24. J-Y Bae, YS Lee, SY Han, HJ Chung, JY Kong, MK Lee, DH Lee, KJ Cho, H-S Lee, M-J Ahn (2012) A comparison between water and ethanol extracts of Rumex acetosa in protective effect on gastric ulcer in mice. Biomolecules & Therapeutics 20(4):425-430. ISSN: 1976-9148 (IF: 3.089) http://dx.doi.org/10.4062/biomolther.2012.20.4.425 Jul 2012
25. M-J Ahn, H Cho, MK Lee, J-Y Bae, J Choi, CY Kim, J Kim (2011) A bisdesmosidic cholestane glycoside from the rhizomes of Polygonatum sibiricum. Natural Product Sciences 17(3): 183-188. ISSN: 1226-3907 Sep 2011 http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=JAKO201129063824609&SITE=CLICK

Patents
AHN, Mi-Jeong, BAE, Ji-Yeong, KIM, Hyun Jin, PARK, Woo Sung. Composition containing improvement of gastric disease by using the ethanolic extract of Rumex acetosa L. (PATENT-10-1531922, JUN 22, 2015), (PCT/KR2013/002244), (Registration No. 1015319220000, JUN 22, 2015) https://doi.org/10.8080/1020140165549
AHN, Mi-Jeong, JANG, Eun Chul, SHIM, Myeong Kuk, LEE, Young Joo, BAE, Ji-Yeong, PARK, Woo Sung, KIM, Hye Jin. The composition for prevention and treatment of thyroid diseases containing the extracts of Macckia amurensis (PATENT-2013-0091208, JUL 31, 2013), (Registration No. 2016838040000, DEC 01, 2016) https://doi.org/10.8080/1020140083002

2015.02 Ph.D. College of Pharmacy, Seoul National University
2010.02 M.S. College of Pharmacy, Seoul National University
2008.02 B.S. College of Pharmacy, Chung- Ang University

2020.04-present Assistant Professor, College of Pharmacy, Jeju National University
2019.01-2020.03 Research Professor, College of Pharmacy, Gyeongsang National University
2016.02-2017.07 Postdoctoral Associate, University of California Los Angeles, Department of chemistry &biochemistry
2015.03-2016.02 Postdoctoral Researcher, Creative Global Pharmacy Researcher Training Project Team, College of Pharmacy, Seoul National University

56. Chan-Hyuk Kwon, Hyoji Choi, Sumi Lee, Min Woo Ha. Pharmacological profiles of Gynostemma Pentaphyllum: A therapeutic candidate from Jeju. Jeju Journal of Island Sciences(제주섬과학회지), 2025, 2(2), 50-59.

55. Yuji Yang, Chan-Hyuk Kwon, Young-Min Ham and Min Woo Ha. Pharmacological Spectrum of Substances Derived from Albizia julibrissin Durazz. Int. J. Mol. Sci. 2025, 26, 7778.

54. Sehun Yang, Jaeyong Lee, Hong Ki Kim, Geumwoo Lee, Min Woo Ha, Kondapalli Pavankumar, Mi-hyun Kim, and Hyeung-geun Park. Highly Enantioselective Synthesis of γ-Carboxy-β-amino Acids via Desymmetric Alcoholysis of 3-Aminoglutaric Anhydrides. Org. Lett. Articles ASAP, 2025, DOI: 10.1021/acs.orglett.5c00955.

53. Mrinmoy Ghosh, Yunji Heo, Krishna Kanth Pulicherla, Min Woo Ha, Kyoungtag Do, Young-Ok Son. Cold-active enzymes from deep marine psychrophiles: harnessing their potential in enhanced food production and sustainability. Crit. Rev. Biotechnol. 2025, 1-25.

52. Jeong-Yong Shin, Min Woo Ha, Ji Hun Kim, Jiwon Cheon, Gum Hwa Lee, Seung-Mann Paek,
and Yunjong Lee. Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and a-synuclein by steroid derivative is neuroprotective in Parkinson’s model. iScience, 2024, 27(11), 111165.

51. Minseok Gi, Daehyun Oh, Sehun Yang, Jaeyong Lee, So Hyun Jung, Ju Ha Baek, Min Woo Ha, Geumwoo Lee and Hyeung-geun Park. Enantioselective Michael addition of 3-hydroxy-2-pyridone to nitroolefins using cinchona-derived bifunctional organocatalysts. Org. Biomol. Chem., 2024, Advance Article. DOI https://doi.org/10.1039/D4OB01042F

50. Chan-Hyuk Kwon and Min Woo Ha. Pharmacogenetic Approach to Tramadol Use in the Arab Population. Int. J. Mol. Sci. 2024, 25, 8939.

49. Godagama Gamaarachchige Dinesh Suminda, Yunhui Min, Min Woo Ha, Mrinmoy Ghosh, Dong-Sun Lee, and Young-Ok Son. In vitro and in vivo investigations on arsenic-induced cartilage degeneration in osteoarthritis. J. Hazard. Mater. 2024, 461, 132570.

48. Shailima Rampogu, Tae Sung Jung, Min Woo Ha, and Keun Woo Lee. Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors. Sci. Rep. 2023, 13(1), 10583.

47. Shailima Rampogu, Baji Shaik, Ju Hyun Kim, Tae Sung Jung, Min Woo Ha, and Keun Woo Lee. Explicit molecular dynamics simulation studies to discover novel natural compound analogues as Mycobacterium tuberculosis inhibitors. Heliyon. 2023, 9(2), e13324.

46. Pooja Singh, Vikas Kumar, Gihwan Lee, Tae Sung Jung, Min Woo Ha, Jong Chan Hong, and Keun Woo Lee. Pharmacophore-Oriented Identification of Potential Leads as CCR5 Inhibitors to Block HIV Cellular Entry. Int. J. Mol. Sci. 2022, 23(24), 16122.

45. Jin-Woong Kim, Jee-Sic Hur, Min Woo Ha, and Soo Kyun Kim. Design of Mobile Application for Learning Chemistry using Augmented Reality. 한국컴퓨터정보학회논문지. 2022, 27(9), 139-147.

44. Geumwoo Lee, Jeong-Hee Lee, Jaeyong Lee, Min Woo Ha, Mi-hyun Kim, Suckchang Hong and Hyeung-geun Park. Asymmetric epoxidation of enones: effect of surfactants, radical scavengers and morphology of catalysts on reaction rates, chemical yields and enantioselectivities in phase-transfer catalysis. Org. Chem. Front. 2022,9, 4902-4909.

43. Vikas Kumar, Shraddha Parate, Danishuddin, Amir Zeb, Pooja Singh, Gihwan Lee, Tae Sung Jung, Keun Woo Lee and Min Woo Ha. 3D-QSAR-based pharmacophore modeling, virtual screening, and molecular dynamics simulations for the identification of spleen tyrosine kinase inhibitors. Front. Cell. Infect. Microbiol. 2022, 12, 909111.

42. Taegwan Kim, Min Woo Ha, and Jonghoon Kim. Recent advances in divergent synthetic strategies for indole-based natural product libraries. Molecules. 2022, 27, 2171.

40. Jaeyong Lee, Jeong Woo Ban, Jeongseok Kim, Sehun Yang, Geumwoo Lee, Lama Prema Dhorma, Mi-hyun Kim, Min Woo Ha, Suckchang Hong, and Hyeung-geun Park. Asymmetric Phase-Transfer Catalytic aza-Michael addition to cyclic enone: highly enantioselective and diastereoselective synthesis of cyclic 1,3-aminoalcohols. Org. Lett. 2022, 24, 1647.

39. Min Woo Ha, Jonghoon Kim, and Seung-Mann Paek. Recent achievements in total synthesis for integral structural revisions of marine natural products. Mar. Drugs. 2022,20, 171.

38. Apoorva M. Kulkarni, Shraddha Parate, Gihwan Lee, Yongseong Kim, Tae Sung Jung, Keun Woo Lee, and Min Woo Ha. Computational simulations highlight the IL2Rα binding potential of polyphenol stilbenes from Fenugreek. Molecules. 2022, 27, 1215.

37. Ae Rin Lee, Seong Bin Park, Si Won Kim, Jae Wook Jung, Jin Hong Chun, Jaesung Kim, Young Rim Kim, Jassy Mary S. Lazarte, Ho Bin Jang, Kim D. Thompson, Myunghwan Jung, Min Woo Ha, and Tae Sung Jung. Membrane vesicles (MVs) from antibiotic-resistant Staphylococcus aureus transfer antibiotic-resistance to antibiotic-susceptible Escherichia coli. J. Appl. Microbiol. 2022, 132,2746.

36. Sung-Cherl Jung, Chang-Hwan Cho, Hye-Ji Kim, Eun-A Ko, Min Woo Ha, and Oh-Bin Kwon. Targeting catecholamines to develop new drugs for attention deficit hyperactivity disorder. J Med Life Sci. 2021, 18, 41.

35. Kalaphath Kounlaxay, Dexiang Yao, Min Woo Ha, and Soo Kyun Kim, Design of virtual reality system for organic chemistry. Intell. Autom. Soft Comput. 2022, 31, 1119.

34. Min Woo Ha and Seung-Mann Paek. Recent advances in the synthesis of ibuprofen and naproxen. Molecules. 2021, 26, 4792.

33. Hae Ju Han, Woong Sub Byun, Gyu Ho Lee, Won Kyung Kim, Kyungkuk Jang, Sehun Yang, Jewon Yang, Min Woo Ha, Suckchang Hong, Jeeyeon Lee, Jongheon Shin, Ki Bong Oh, Sang Kook Lee, and Hyeung-geun Park. Synthesis and biological activity of seleno-psammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. Bioorg. Med. Chem. 2021, 35, 116072.

32. Jewon Yang, Yohan Park, Sehun Yang, Geumwoo Lee, Min Woo Ha, Mi-hyun Kim, Suckchang Hong, and Hyeung-geun Park. Enantioselective total synthesis of Nitraria alkaloids, (+)-Nitramine, (+)-Isonitramine, (-)-Isonitramine, and (-)-Sibirine via asymmetric Phase-transfer Catalytic α-allylations of α-carboxylactams. J. Org. Chem. 2021, 86, 4375.

31. Min Woo Ha†, Chul Woong Joo†, Jiyong Park†, JunHo Hwa, Hyein Jeong, Jonghee Lee, and Yun-Hi Kim. Ancillary ligand effect with methyl and t-butyl for deep blue and high EQE blue phosphorescent organic light-emitting diodes (†co-first author). Chem. Eng. J. 2021, 411, 128437.

30. Si Won Kim, Jong Su Seo, Seong Bin Park, Ae Rin Lee, Jung Seok Lee, Jae Wook Jung, Jin Hong Chun, Jassy Mary S. Lazarte, Jaesung Kim, Jong Hwan Kim, Jong Wook Song, Chris Franco, Wei Zhang, Min Woo Ha, Seung-Mann Paek, Myunghwan Jung, and Tae Sung Jung. Significant increase in the secretion of extracellular vesicles and antibiotics resistance from methicillin-resistant Staphylococcus aureus induced by ampicillin stress. Sci. Rep. 2020, 10, 21066.

29. Sanggi Lee, Jewon Yang, Sehun Yang, Geumwoo Lee, Daehyun Oh, Min Woo Ha, Suckchang Hong, and Hyeung-geun Park. Synthesis of (+)-Coerulescine by a Phase-transfer Catalytic allylation of diphenylmethyl tert-butyl a-(2-nitrophenyl)malonate. Front. Chem. 2020, 8, 577371.

28. Min Woo Ha, Sung Wook Yi, and Seung-Mann Paek. Design and synthesis of small molecules as potent Staphylococcus aureus sortase A inhibitors. Antibiotics. 2020, 9, 706.

27. Min Woo Ha†, Min-Ho Park†, Jae Young Hwang, Jingwan Kim, Dong-Hyeok Kim, Tae-Woo Lee, and Yun-Hi Kim. Synthesis and characterization of homoleptic triply cyclometalated iridium (III) complex containing 6-(pyridin-2-yl)isoquinoline moiety for solution-processable orange-phosphorescent organic light-emitting diodes (†co-first authors). Dyes and Pigm. 2021, 185, 108880.

26. Si Won Kim, Jung Seok Lee, Seong Bin Park, Ae Rin Lee, Jae Wook Jung, Jin Hong Chun, Jassy Mary S. Lazarte, Jaesung Kim, Jong-Su Seo, Jong-Hwan Kim, Jong-Wook Song, Min Woo Ha, Kim D. Thompson, Chang-Ro Lee, Myunghwan Jung, and Tae Sung Jung. The importance of porins and β-lactamase in outer membrane vesicles on the hydrolysis of β-lactam antibiotics. Int. J. Mol. Sci. 2020, 21, 2822.

25. Sunyoung Sohn†, Min Woo Ha†, Jiyong Park, Yoo-Heon Kim, Hyungju Ahn, Sungjune Jung, Soon-Ki Kwon, and Yun-Hi Kim. High-efficiency diphenylpyrimidine derivatives blue thermally activated delayed fluorescence organic light-emitting diodes (†co-first authors). Front. Chem. 2020, 8, 356.

24. Jae Wook Jung, Jung Seok Lee, Jaesung Kim, Se Pyeong Im, Si Won Kim, Jassy Mary S. Lazarte, Young Rim Kim, Jin Hong Chun, Min Woo Ha, Na Na Kim, Kim D. Thompson, Hyoung Jun Kim, and Tae Sung Jung. Involvement of CD4-1 T cells in the cellular immune response of olive flounder (Paralichthys olivaceus) against viral hemorrhagic septicemia virus (VHSV) and nervous necrosis virus (NNV) infection. Dev. Comp. Immunol. 2020, 103, 103518.

23. Jae Wook Jung, Jung Seok Lee, Jaesung Kim, Se Pyeong Im, Si Won Kim, Jassy Mary S. Lazarte, Young Rim Kim, Jin Hong Chun, Min Woo Ha, Hyeong Su Kim, Kim D. Thompson and Tae Sung Jung. Characterization of hagfish (Eptatretus burgeri) variable lymphocyte receptor-based antibody and its potential role in the neutralization of nervous necrosis virus. J. Immunol. 2020, 204, 718.

22. Min Woo Ha, Bo Reum Song, Hye Jin Chung, and Seung-Mann Paek. Design and synthesis of anti-cancer chimera molecules based on marine natural products. Mar. Drugs. 2019, 17, 500.

21. Bo Reum Song, Min Woo Ha, Donghwan Kim, Chanin Park, Keun Woo Lee, and Seung-Mann Paek. Investigation of Grignard reagent as an advanced base for aza-Claisen rearrangement. Molecules. 2019, 24, 4597.

20. So Hyun Jung, Byungsoo Kim, Cheonhyoung Park, Jeongseok Kim, Min Woo Ha, Suckchang Hong, and Hyeung-geun Park. Enantioselective synthesis of chiral α­alkylthiomalonates via a phase­transfer­catalyzed α­sulfenylation of α­alkylmalonates. Asian J. Org. Chem. 2019, 8, 1732.

19. Ae-Hyang Kim, Min Woo Ha, Jun Il Kim, Zhe Piao, Yong Chul Shin, and Daekeun Shin. Beneficial effect of collagen hydrolysate containing collagen tripeptides on ultraviolet B-induced skin photoaging. 한국식품과학회지, 2019, 51, 466.

18. Min Woo Ha, Jun Young Lee, Doyoung Kim, Geumwoo Lee, Jae Kyun Lee, Suckchang Hong, and Hyeung-geun Park. Enantioselective synthesis of chiral α-thio-quaternary stereogenic centers via phase-transfer-catalyzed α-alkylation of α-acylthiomalonates. J. Org. Chem. 2018, 83, 1011.

17. Ae-Hyang Kim, Yi-Soo Kim, Zhe Piao, Yong Chul Shin, and Min Woo Ha. Cutaneous hydration effect of collagen hydrolysate containing collagen tripeptides. 한국식품과학회지, 2018, 50, 420.

16. Doyoung Kim, Min Woo Ha, Suckchang Hong, Cheonhyoung Park, Byungsoo Kim, Jewon Yang, and Hyeung-geun Park. Enantioselective synthesis of chiral α-azido and α-aryloxy quaternary stereogenic centers via the phase-transfer-catalyzed α-alkylation of α-bromomalonates, followed by SN2 substitution. J. Org. Chem. 2017, 82, 4936.

15. Min Woo Ha, Sujee Choi, Seek Kim, Jun Young Lee, Suckchang Hong, and Hyeung-geun Park. Phase-transfer catalyzed enantioselective α-alkylation of α-acyloxymalonates: construction of chiral α-hydroxy quaternary stereogenic centers. RSC Adv. 2016, 6, 77427.

14. Pramod K. Sahu, Gyudong Kim, Akshata Nayak, Ji Yoon Ahn, Min Woo Ha, Cheonhyoung Park, Jinha Yu, Hyeung-geun Park, and Lak Shin Jeong: Synthesis of acyclic selenonucleoside phosphonates as potential antiviral agents. Asian J. Org. Chem. 2016, 5, 183.

13. Jae-Young Lee, Mee Yeon Lee, Min Woo Ha, Tae Hyung Won, Hyun-Jong Cho, Jongheon Shin, Hyeung-geun Park, and Dae-Duk Kim. Determination and validation of Psammaplin A and its derivatives in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study. J. Chromatogr. B. 2015, 1000, 155.

12. Cheonhyoung Park, Min Woo Ha, Byung Soo Kim, Suckchang Hong, Doyoung Kim, Yohan Park, Mi-hyun Kim, Jae Kyun Lee, Jeeyeon Lee, and Hyeung-geun Park. Enantioselective α-alkylation of benzylideneamino tert-butyl malonates by phase transfer catalysis. Adv. Synth. Catal. 2015, 357, 2841.

11. Suckchang Hong, Yoonho Shin, Myunggi Jung, Min Woo Ha, Yohan Park, Yeon-Ju Lee, Jongheon Shin, Ki Bong Oh, Sang Kook Lee, and Hyeung-geun Park. Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents. Eur. J. Med. Chem. 2015, 96, 218.

10. Min Woo Ha, Myungmo Lee, Sujee Choi, Seek Kim, Suckchang Hong, Yohan Park, Mi-hyun Kim, Taek-Soo Kim, Jihoon Lee, Jae Kyun Lee, and Hyeung-geun Park. Construction of chiral α-amino quaternary stereogenic centers via phase-transfer catalyzed enantioselective α-alkylation of α-amidomalonates. J. Org. Chem. 2015, 80, 3270.

9. Suckchang Hong, Minsik Kim, Myunggi Jung, Min Woo Ha, Myungmo Lee, Yohan Park, Mi-hyun Kim, Taek-Soo Kim, Jihoon Lee, and Hyeung-geun Park. Enantioselective synthesis of α-halo-α-alkylmalonates via phase-transfer catalytic α-alkylation. Org. Biomol. Chem. 2014, 12, 1510.

8. Jisung Jung, Suryeon Park, Suckchang Hong, Min Woo Ha, Hyeung-geun Park, Youmie Park, Hyo-Jong Lee, and Yohan Park. Synthesis of gold nanoparticles with glycosides: synthetic trends based on the structures glycones and aglycones. Carbohydr. Res. 2014, 386, 57.

7. Suckchang Hong, Myunggi Jung, Yohan Park, Min Woo Ha, Cheonhyoung Park, Myungmo Lee, and Hyeung-geun Park. Efficient enantioselective total synthesis of (-)-Horsfiline. Chem. Eur. J. 2013, 19, 9599.

6. Min Woo Ha, Suckchang Hong, Cheonhyoung Park, Yohan Park, Jihye Lee, Mi-hyun Kim, Jihoon Lee, and Hyeung-geun Park. Enantioselective phase-transfer catalytic α-alkylation of 2-methylbenzyl tert-butyl malonates. Org. Biomol. Chem. 2013, 11, 4030.

5. Myungmo Lee, Young-Ju Lee, Eunyoung Park, Yohan Park, Min Woo Ha, Suckchang Hong, Yeon-Ju Lee, Taek-Soo Kim, Mi-hyun Kim, and Hyeung-geun Park. Highly enantioselective synthesis of 5-phenyl-2-alkylprolines using phase-transfer catalytic alkylation. Org. Biomol. Chem. 2013, 11, 2039.

4. Min Woo Ha, Heejin Lee, Hye Yeong Yi, Yohan Park, Sori Kim, Suckchang Hong, Myungmo Lee, Mi-hyun Kim, Taek-Soo Kim, and Hyeung-geun Park. Enantioselective phase-transfer catalytic α-benzylation and α-allylation of α-tert-butoxycarbonyllactones. Adv. Synth. Catal. 2013, 355, 637.

3. Mi-Sook Yoo, Dong-Guk Kim, Min Woo Ha, Sang-sup Jew, Hyeung-geun Park, and Byeong-Seon Jeong. Synthesis of (αR,βS)-epoxyketones by asymmetric epoxidation of chalcones with cinchona phase-transfer catalysts. Tetrahedron Lett. 2010, 51, 5601.

2. Sukhoon Kang, Qinghua Shi, Min Woo Ha, Jin-Mo Ku, Maosheng Cheng, Byeong-Seon Jeong, Hyeung-geun Park, and Sang-sup Jew. Enantioselective synthesis of (S)-4-methylene glutamic acid via tandem conjugate addition-elimination under phase-transfer catalytic conditions. Tetrahedron. 2010, 66, 4326.

1. Jihye Lee, Min Woo Ha, Taek-Soo Kim, Mi-Jeong Kim, Jin-Mo Ku, Sang-sup Jew, Hyeung-geun Park, and Byeong-Seon Jeong. Solid-phase synthesis of α-alkyserine via phase-transfer catalytic alkylation of polymer-supported 2-phenyl-2-oxazoline-4-carboxylate. Tetrahedron. 2009, 65, 8839.

2010.02 Ph.D. College of Medicine, Seoul National University
2004.02 M.S. College of Pharmacy, Chung-Ang University
2002.02 B.S. College of Pharmacy, Chung-Ang University

2020.09-present Assistant/Associate Professor, College of Pharmacy, Jeju National University
2018.03-2020.08 BK Assistant Professor, Biomedical Science Project, Seoul National University College of Medicine
2010.09-2018.02 Senior Scientist, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine

1. Lee SJ, Lee KB, Hong AY, Son YH, Lee DH, Jeong EM, Kim IG. Transglutaminase 2 mediates UVB-induced matrix metalloproteinase-1 expression by inhibiting nuclear p65 degradation in dermal fibroblasts. Exp Dermatol. 2021 Dec 9.
2. Kim YC, Kim J, Kim S, Bae B, Kim RL, Jeong EM, Cho SH, Kang HR. Transglutaminase 2 mediates lung inflammation and remodeling by transforming growth factor beta 1 via alveolar macrophage modulation. Exp Lung Res. 2021 Dec;47(10):465-475.
3. Lim J, Heo J, Yu HY, Yun H, Lee S, Ju H, Nam YJ, Jeong SM, Lee J, Cho YS, Choo MS, Jeong EM, Ryu CM, Shin DM. Small-sized mesenchymal stem cells with high glutathione dynamics show improved therapeutic potency in graft-versus-host disease. Clin Transl Med. 2021 Jul;11(7):e476.
4. Jung HR, Oh Y, Na D, Min S, Kang J, Jang D, Shin S, Kim J, Lee SE, Jeong EM, An JY, Sung CO, Lee WS, Lee C, Cho SY. CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers. Oncogene. 2021 May;40(18):3287-3302.
5. Kim HJ, Lee JH, Lee KB, Shin JW, Kwon MA, Lee S, Jeong EM, Cho SY, Kim IG. Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding protein-protein interactions of the fused protein. Exp Mol Med. 2021 Jan;53(1):115-124.
6. Oh Y, Jung HR, Min S, Kang J, Jang D, Shin S, Kim J, Lee SE, Sung CO, Lee WS, Lee C, Jeong EM*, Cho SY*. Targeting antioxidant enzymes enhances the therapeutic efficacy of the BCL-XL inhibitor ABT-263 in KRAS-mutant colorectal cancers. Cancer Lett. 2020 Oct 15;497:123-136. (*Co-corresponding authors)
7. Cho SY, Oh Y, Jeong EM, Park S, Lee D, Wang X, Zeng Q, Qin H, Hu F, Gong H, Liu X, Zhang G, Na D, Lee J, Chae J, Suh YS, Kong SH, Lee HJ, Kim JI, Park H, Zhang C, Yang HK, Lee C. Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers. Exp Mol Med. 2020 May;52(5):854-864.
8. Lee KB, Shin JW, Kwon MA, Kang H, Kim HM, Lee SJ, Jeong EM, Kang HS, Kim IG. Antioxidants reduce the heterogeneity of the intracellular glutathione level in senescent cell population of human dermal fibroblasts. J Dermatol Sci. 2020 Jun;98(3):195-198.
9. Shin JW, Kwon MA, Hwang J, Lee SJ, Lee JH, Kim HJ, Lee KB, Lee SJ, Jeong EM, Chung JH, Kim IG. Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation. Cell Death Dis. 2020 Apr 30;11(4):301.
10. Lim J, Heo J, Ju H, Shin JW, Kim YH, Lee S, Yu HY, Ryu CM, Yun HD, Song S, Hong KS, Chung HM, Kim HR, Roe JS, Choi K, Kim IG, Jeong EM*, Shi DM*. Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1？NRF2 pathway. Science Advances. 2020 Apr 15;6:eaba1334 (*Co-corresponding authors)
11. Cho SY, Lee S, Yeom J, Kim HJ, Lee JH, Shin JW, Kwon MA, Lee KB, Jeong EM, Ahn HS, Shin DM, Kim K, Kim IG. Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs. Life Sci Alliance. 2020 Feb 19;3(3):e201900565.
12. Jeong EM*, Lee KB*, Kim GE, Kim CM, Lee JH, Kim HJ, Shin JW, Kwon MA and Park HH, Kim IG. Competitive binding of magnesium to calcium binding sites reciprocally regulates transamidase and GTP hydrolysis activity of transglutaminase 2. International Journal of Molecular Sciences. 2020 Jan 25; 21(3):791. (*Co-first authors)
13. Jeong EM*, Shin JW*, Lim J*, Kim JH, Kang H, Yin Y, Kim HM, Kim Y, Kim SG, Kang HS, Shin DM, Choi K, Kim IG. Monitoring Glutathione Dynamics and Heterogeneity in Living Stem Cells. International Journal of Stem Cells. 2019 Jul 31;12(2):367-379. (*Co-first authors) Selected for cover image.
14. Ha HJ*, Kwon S*, Jeong EM*, Kim CM, Lee KB, Kim IG, Park HH. Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity. PLoS ONE. 2018 Oct 15;13(10):e0204707. (*Co-first authors)
15. Jeong EM*, Jin CZ*, Jang JH, Zhao JH, Jin CL, Lee JH, Lee KB, Kim SJ, Kim IG, Zhang YH. S-Nitrosylation of transglutaminase2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes. Experimental & molecular medicine. 2018 Apr 6;50(4):9. (*Co-first authors)
16. Jeong EM, Yoon JH, Lim J, Shin JW, Cho AY, Heo J, Lee KB, Lee JH, Lee WJ, Kim HJ, Son YH, Lee SJ, Cho SY, Shin DM, Choi K, Kim IG. Real-time monitoring of glutathione in living cells reveals a requirement of its high levels for maintaining stem cell function. Stem Cell Reports. 2018 Feb 13;10(2):600-614.
17. Lee SJ, Lee KB, Son YH, Shin J, Lee JH, Kim HJ, Hong AY, Bae HW, Kwon MA, Lee WJ, Kim JH, Lee DH, Jeong EM*, Kim IG*. Transglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production. Cell Death & Disease. 2017 Oct 26;8(10):e3148. (*Co-corresponding authors)
18. Kim WS, Kim H, Jeong EM, Kim HJ, Lee ZH, Kim IG, Kim HH. Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway. Sci Rep. 2017 Sep 6;7(1):10626.
19. Lee SJ, Son YH, Lee KB, Lee JH, Kim HJ, Jeong EM, Park SC, Kim IG. 4-n-butylresorcinol enhances proteolytic degradation of tyrosinase in B16F10 melanoma cells. Int J Cosmet Sci. 2017 Jun;39(3):248-255.
20. Heo J, Lim J, Lee S, Jeong J, Kang H, Kim Y, Kang JW, Yu HY, Jeong EM, Kim K, Kucia M, Waigel SJ, Zacharias W, Chen Y, Kim IG, Ratajczak MZ, Shin DM. Sirt1 regulates DNA methylation and differentiation potential of embryonic stem cells by antagonizing Dnmt3l. Cell Reports. 2017 Feb 21;18(8):1930-1945.
21. Jeong EM*, Son YH*, Choi Y, Kim JH, Lee JH, Cho SY, Kim IG. Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis. Experimental & molecular medicine. 2016 Nov 4;48(11):e267. (*Co-first authors)
22. Kim Y, Kim TW, Park YS, Jeong EM, Lee DS, Kim IG, Chung H, Hwang YI, Lee WJ, Yu HG, Kang JS. The role of interleukin-22 and its receptor in the development and pathogenesis of experimental autoimmune uveitis. PLoS One. 2016 May 11;11(5):e0154904.
23. Hong C, Seo H, Kwak M, Jeon J, Jang J, Jeong EM, Myeong J, Hwang YJ, Ha K, Kang MJ, Lee KP, Yi EC, Kim IG, Jeon JH, Ryu H, So I. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease. Brain. 2015 Oct;138(Pt 10):3030-47.
24. Cho SY, Lee JH, Ju MK, Jeong EM, Kim HJ, Lim J, Lee S, Cho NH, Park HH, Choi K, Jeon JH, Kim IG. Cystamine induces AIF-mediated apoptosis through glutathione depletion. Biochim Biophys Acta. 2015 Mar;1853(3):619-31.
25. Son YH, Lee SJ, Lee KB, Lee JH, Jeong EM, Chung SG, Park SC, Kim IG. Dexamethasone downregulates caveolin-1 causing muscle atrophy via inhibited insulin signaling. J Endocrinol. 2015 Apr;225(1):27-37.
26. Jang TH, Lee DS, Choi K, Jeong EM, Kim IG, Kim YW, Chun JN, Jeon JH, Park HH. Crystal Structure of Transglutaminase 2 with GTP Complex and Amino Acid Sequence Evidence of Evolution of GTP Binding Site. PLoS One. 2014 Sep 5;9(9):e107005.
27. Kim JH, Hong JM, Jeong EM, Lee WJ, Kim HR, Kang JS, Kim IG, Hwang YI. Lack of transglutaminase 2 diminished T-cell responses in mice. Immunology. 2014 Jul;142(3):506-16.
28. Lee JH, Jeong J, Jeong EM, Cho SY, Kang JW, Lim J, Heo J, Kang H, Kim IG, Shin DM. Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation. Int J Mol Med. 2014 Apr;33(4):849-55.
29. Min SK, Min SI, Jeong EM, Cho SY, Ha J, Kim SJ, Kim IG. Intimal Hyperplasia in Loop-Injured Carotid Arteries Is Attenuated in Transglutaminase 2-Null Mice. J Korean Med Sci. 2014 Mar;29(3):363-9.
30. Kim JH, Jeong EM, Jeong YJ, Lee WJ, Kang JS, Kim IG, Hwang YI. Transglutaminase 2 on the surface of dendritic cells is proposed to be involved in dendritic cell-T cell interaction. Cell Immunol. 2014 May-Jun;289(1-2):55-62.
31. Lee SM*, Jeong EM*, Jeong J, Shin DM, Lee HJ, Kim HJ, Lim J, Lee JH, Cho SY, Kim MK, Wee WR, Lee JH, Kim IG. Cysteamine Prevents the Development of Lens Opacity in a Rat Model of Selenite-Induced Cataract. Investigative ophthalmology & visual science. 2012 Mar 15;53(3):1452-9. (*Co-first authors)
32. Cho SY, Jeong EM, Lee JH, Kim HJ, Lim J, Kim CW, Shin DM, Jeon JH, Choi K, Kim IG. Doxorubicin Induces the Persistent Activation of Intracellular Transglutaminase 2 That Protects from Cell Death. Mol Cells. 2012 Mar;33(3):235-41.
33. Kim JH, Jeong EM, Jeong YJ, Lee WJ, Kang JS, Kim IG, Hwang YI. Transglutaminase 2 modulates antigen-specific antibody response by suppressing Blimp-1 and AID expression of B cells in mice. Immunol Lett. 2012 Sep;147(1-2):18-28.
34. Jeong EM, Ahn KH, Jeon HJ, Kim HD, Lee HS, Jung SY, Jung KM, Kim SK, Bonventre JV, Kim DK. Purification and characterization of a cytosolic Ca2+-independent phospholipase A2 from bovine brain. Molecules and cells. 2011 Nov;32(5):405-13.
35. Oh K, Park HB, Byoun OJ, Shin DM, Jeong EM, Kim YW, Kim YS, Melino G, Kim IG, Lee DS. Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice. Journal of experimental medicine. 2011 Aug 1;208(8):1707-19.
36. Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG. Transglutaminase 2 inhibits apoptosis induced by calcium-overload through down-regulation of Bax. Exp Mol Med. 2010 Sep 30;42(9):639-50.
37. Cho SY, Jeon JH, Kim CW, Shin DM, Jang GY, Jeong EM, Lee SE, Song KY, Kim IG. Monoclonal Antibodies to Human Transglutaminase 4. Hybridoma (Larchmt). 2010 Jun;29(3):263-7.
38. Cho SY, Choi K, Jeon JH, Kim CW, Shin DM, Lee JB, Lee SE, Kim CS, Park JS, Jeong EM, Jang GY, Song KY, Kim IG. Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer. Exp Mol Med. 2010 Apr 30;42(4):310-8.
39. Jang GY, Jeon JH, Cho SY, Shin DM, Kim CW, Jeong EM, Bae HC, Kim TW, Lee SH, Choi Y, Lee DS, Park SC, Kim IG. Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappa B activity in hypoxic tumor cells. Oncogene. 2010 Jan 21;29(3):356-67.
40. Jeong EM*, Kim CW*, Cho SY, Jang GY, Shin DM, Jeon JH, Kim IG. Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress. FEBS letters. 2009 Feb 18;583(4):648-54 (*Co-first authors)
41. Shin DM, Jeon JH, Kim CW, Cho SY, Lee HJ, Jang GY, Jeong EM, Lee DS, Kang JH, Melino G, Park SC, Kim IG. TGF beta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation. FASEB J. 2008 Jul;22(7):2498-507.
42. Jung SM, Jeong EM, Jo DH, Chin MR, Jun HJ, Kim YH, Jeon HJ, Lee DH, Park MJ, Oh MJ, Yim CB, Kim DK. Inhibition of a Neutral Form of Sphingomyelinase by Alkylthioureido-1,3-propandiols, KY353X Series. Biomolecules & Therapeutics. 2003 11(3) 169-173

Books
1. EM Jeong, IG Kim. Regulation of Transglutaminase 2 by Oxidative Stress. Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer 2015 315-331

2013 Ph.D. College of Pharmacy, Seoul National University
2006 B.S. College of Pharmacy, Seoul National University

2020.09-present Assistant Professor, College of Pharmacy, Jeju National University
2019-2020 Research Fellow, Department of Immunology, Harvard Medical School
2013-2019 Postdoctoral researcher, College of Pharmacy, Seoul National University

1. Kim E, Paik D, Ramirez RN, Biggs DG, Park Y, Kwon HK, Choi GB, and Huh JR. Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells. Immunity, 55(1):145-158, 2022
2. Choi G, Park YJ, Cho M, Moon H, Kim D, Kang CY, Chung Y, Kim BS. A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells. Exp Mol Med, 53(5):993-1004, 2021
3. Kim BS, Kuen DS, Koh CH, Kim HD, Chang SH, Kim S, Jeon YK, Park YJ, Choi G, Kim J, Kang KW, Kim HY, Kang SJ, Hwang S, Shin EC, Kang CY, Dong C, Chung Y. Type 17 immunity promotes the exhaustion of CD8+ T cells in cancer. J Immunother Cancer, 9(6):e002603, 2021
4. Song B, Lee JM, Park YJ, Kim IK, Kim BS, Shin KS, Jeon I, Koh CH, Bae EA, Seo H, Byun Y, and Kang CY. Differentiation of c-Kit+ CD24+ natural killer cells into myeloid cells in a GATA-2-dependent manner. Faseb Journal, 34(3):4462-4481, 2020.
5. Park YJ*, Cho M*, Choi G, Na H, and Chung Y. A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3. Biomolecules, 10(1):122, 2020 (*These authors contributed equally to this work).
6. Shin KS, Jeon I, Kim BS, Kim IK, Park YJ, Koh CH, Song B, Lee JM, Lim J, Bae EA, Seo H, Ban YH, Ha SJ, and Kang CY. Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection. Frontiers in Immunology, 10:1887, 2019.
7. Lee KY, Lee W, Jung SH, Park J, Sim H, Choi YJ, Park YJ, Chung Y, and Lee BH. Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice. Biochemical Pharmacology, 166:46-55, 2019.
8. Park YJ, Ryu H, Choi G, Kim BS, Hwang ES, Kim HS, and Chung Y. IL-27 confers a pro-tumorigenic activity of regulatory T cells via CD39. Proceedings of the National Academy of Sciences of the United States of America, 116(8):3106-3111, 2019.
9. Park YJ, Kuen DS, and Chung Y. Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance. Experimental & Molecular Medicine, 50(8):109, 2018.
10. Cho M, Lee JE, Lim H, Shin HW, Khalmuratova R, Choi G, Kim HS, Choi WS, Park YJ, Shim I, Kim BS, Kang CY, Kim JO, Tanaka S, Kubo M, Tung HY, Landers CT, Corry DB, Kheradmand F, and Chung Y. Fibrinogen cleavage products and Toll-like receptor 4 promote the generation of programmed cell death 1 ligand 2-positive dendritic cells in allergic asthma. Journal of Allergy and Clinical Immunology, 142(2):530-541, 2018.
11. Ryu H, Lim H, Choi G, Park YJ, Cho M, Na H, Ahn CW, Kim YC, Kim WU, Lee SH, and Chung Y. Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27. Nature Immunology, 19(6):583-593, 2018.
12. Lee JE, Lee JM, Park YJ, Kim BS, Jeon YT, and Chung Y. Inhibition of autoimmune Th17 cell responses by pain killer ketamine. Oncotarget, 8(52):89475-89485, 2017.
13. Choi G, Kim BS, Park YJ, Shim I, and Chung Y. Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes. Immune Network, 17(3):163-170, 2017.
14. Kim BS*, Park YJ*, and Chung Y. Targeting IL-17 in autoimmunity and inflammation. Archives of Pharmacal Research, 39(11):1537-1547, 2016. (*The authors have equally contributed to this work.)
15. Lee JS, Kang JH, Boo HJ, Hwang SJ, Hong S, Lee SC, Park YJ, Chung TM, Youn H, Lee SM, Kim BJ, Chung JK, Chung Y, William WN Jr, Shin YK, Lee HJ, Oh SH, and Lee HY. STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody. Nature Communications, 14(6): 8499, 2015.
16. Kim EK, Jeon I, Seo H, Park YJ, Song B, Lee KA, Jang Y, Chung Y, and Kang CY. Tumor-derived osteopontin suppresses anti-tumor immunity by promoting extramedullary myelopoiesis. Cancer Research, 74:6705-6716, 2014.
17. Kim EK, Seo HS, Chae MJ, Jeon IS, Song BY, Park YJ, Ahn HM, Yun CO, and Kang CY. Enhanced antitumor immunotherapeutic effect of B-cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures. Gene Therapy, 21(1):106-114, 2014.
18. Lee JM, Kim EK, Chae MJ, Park YJ, Song BY, Seo HS, Kim YS, Kim YJ, Ko HJ, and Kang CY. Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid-derived suppressor cells via TLR2-dependent STAT3 activation. European Journal of Immunology, 44(6):1672-1684, 2014.
19. Park YJ, Song B, Kim YS, Kim EK, Lee JM, Lee GE, Kim JO, Kim YJ, Chang WS, and Kang CY. Tumor microenvironmental conversion of natural killer cells into myeloid-derived suppressor cells. Cancer Research 73(18):5669-5681, 2013. (selected as a ‘cover article’)
20. Kim YS, Kim YJ, Lee JM, Kim EK, Park YJ, Choe SK, Ko HJ, and Kang CY. Functional changes in myeloid-derived suppressor cells (MDSCs) during tumor growth: FKBP51 contributes to the regulation of the immunosuppressive function of MDSCs. The Journal of Immunology 188(9), 4226-4234, 2012.
21. Kim BS, Kim IK, Park YJ, Kim YS, Kim YJ, Chang WS, Lee YS, Kweon MN, Chung Y, and Kang CY. Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma. Proceedings of the National Academy of Sciences of the United States of America 107(19), 8742-8747, 2010.

Feb 2006 B.S. in Pharmacy, College of Pharmacy, Seoul National University
Aug 2013 Ph.D. in Pharmacy, College of Pharmacy, Seoul National University

Mar 2021 - present Assistant Professor, College of Pharmacy, Jeju National University, Jeju, Republic of Korea
Jun 2020 - Feb 2021 Research Professor, Research Institute for Drug Development (RIDD), Pusan National University, Pusan, Republic of Korea
Jan 2016 - Apr 2020 Postdoctoral Researcher, School of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA
Apr 2014 - Dec 2015 Postdoctoral Researcher, Risk Assessment Division, Environmental Health Research Department, National Institute of Environmental Research (NIER), Incheon, Republic of Korea
Sep 2013 - Apr 2014 Postdoctoral Researcher, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

46. Seo J*, Kwon D*, Kim SH, Byun MR, Lee YH, Jung YS. Role of autophagy in betaine-promoted hepatoprotection against non-alcoholic fatty liver disease in mice. (2023.12.) Curr Res Food Sci. 8:100663.
*Co-first authors

45. Kim HJ, Yang J, Herath KHINM, Jeon YJ, Son YO, Kwon D, Kim HJ, Jee Y. Oral Administration of Sargassum horneri Suppresses Particulate Matter-Induced Oxidative DNA Damage in Alveolar Macrophages of Allergic Airway Inflammation: Relevance to PM-Mediated M1/M2 AM Polarization. (2023.12.) Mol Nutr Food Res. 67(24):e2300462.

44. Kim SH*, Yun C*, Kwon D*, Lee YH, Kwak JH, Jung YS. (2023.02) Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells. Molecules, 28(3):1476
*Co-first authors

43. Lee S, Bae JE, Kwon D*, Jung YS* (2022.12.) Effect of Diet Restriction on Renal Glutathione Metabolism in Mice, Journal of the Pharmaceutical Society of Korea, 66(6):331.
*Co-corresponding authors

42. Kwon D, Son SW, Kim SH, Bae JE, Lee YH, Jung YS (2022.10.) Effects of dietary restriction on hepatic sulfur-containing amino acid metabolism and its significance in acetaminophen-induced liver injury, J Nutr Biochem, 108:109082.

41. Kwon D, Lee W, Kim SH, Jung YS (2022.09) Comparison of Hepatic Metabolite Profiles between Infant and Adult Male Mice Using 1H-NMR-Based Untargeted Metabolomics. Metabolites, 12(10), 910.

40. Kim SH*, Seo HJ*, Kwon D*, Yuk DY, Jung YS. (2022.02.) Taurine Ameliorates Tunicamycin-Induced Liver Injury by Disrupting the Vicious Cycle between Oxidative Stress and Endoplasmic Reticulum Stress, Life (Basel), 12(3):354.
*Co-first authors

39. Kim SH, Choi HJ, Seo HJ, Kwon D, Yoon J, Jung YS (2021. 12.) Downregulation of Glutathione-Mediated Detoxification
Capacity by Binge Drinking Aggravates Acetaminophen Induced Liver Injury through IRE1α ER Stress Signaling, Antioxidants, 10(12):1949

38. Kim SH*, Kim M*, Kwon D*, Pyo JS, Kim JH, Kwak JH, Jung YS (2021. 02.) N-Phenyl Cinnamamide Derivatives Protect Hepatocytes Against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation, Molecules, 15;26(4):1027
*Co-first authors

37. Kim SH*, Kwon D*, Son SW*, Jeong TB, Lee S, Kwak JH, Cho JY, Hwang DY, Seo MS, Kim KS, Jung YS (2021. 01.) Inflammatory responses of C57BL/6NKorl mice to dextran sulfate sodium-induced colitis: comparison between three C57BL/6 N sub-strains, Lab Anim Res, 28;37(1):8.
*Co-first authors

36. Liu Y, Trnka MJ, Guan S, Kwon D, Kim DH, Chen JJ, Greer PA, Burlingame AL, Correia MA. (2020. 12.) A Novel Mechanism For NF-κB Activation Via IκB Aggregation: Implications For Hepatic Mallory-Denk-Body Induced Inflammation, Molecular & Cellular Proteomics, 19(12):1968-1985.

35. Correia MA, Kwon D. (2020. 11.) Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models, Biology (Basel), 126;9(12):419.

34. Kwon D, Kim SH, Son SW, Seo J, Jeong TB, Kim KM, Jung JC, Jung MS, Lee YH, Jung YS (2020. 11.) Germinated Soybean Embryo Extract Ameliorates Fatty Liver Injury in High-Fat Diet-Fed Obese Mice, Pharmaceuticals, 13(11), 380.

33. Kim M, Im S, Cho YK, Choi C, Son Y, Kwon D, Jung YS, Lee YH (2020. 09.) Antiobesity effects of soybean embryo extract and enzymatically-modifed isoquercitrin. Biomolecules, 10(10), E1394.

32. Kim S, Lee S, Lee H, Ju S, Park S, Kwon D, Yoo JW, Yoon IS, Min DS, Jung YS, Jung Y (2020. 09.) A colon-targeted prodrug, 4-phenylbutyric acid-glutamic acid conjugate, ameliorates 2,4-dinitrobenzenesulfonic acid-induced colitis in rats. Pharmaceutics, 12, 843

31. Kim SH*, Kwon D*, Lee S, Son SW, Kwon JT, Kim PJ, Lee YH, Jung YS (2020
. 03.) Concentration- and Time-Dependent Effects of Benzalkonium Chloride in Human Lung Epithelial Cells: Necrosis, Apoptosis, or Epithelial Mesenchymal Transition, Toxics, 8(1), 17
*Co-first authors

30. Jeong TB*, Kwon D*, Son SW, Kim SH, Lee YH, Seo MS, Kim K, Jung YS (2020. 03.) Weaning Mice and Adult Mice Exhibit Differential Carbon Tetrachloride-Induced Acute Hepatotoxicity, Antioxidants, 9(3), 201 *Co-first authors

29. Kim SH, Lee W, Kwon D, Lee S, Son SW, Seo MS, Kim KS, Lee YH, Kim S, Jung YS (2020. 02.) Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut？Liver Connection, Cells, 9(2), 341

28. Kwon D, Kim SM, Correia MA (2020. 01.) Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): Therapeutic and pathophysiological implications, Acta Pharmaceutica Sinica B, 10(1):42-60, doi: 10.1016/j.apsb.2019.11.002

27. Kwon D, Kim SM, Jacob P 3rd, Liu Y, Correia MA (2019. 11.) Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance, Molecular Pharmacology, 96(5):641-654, doi: 10.1124/mol.119.117069

26. Kim SH*, Kwon D*, Lee S, Ki SH, Jeong HG, Hong JT, Lee YH, Jung YS (2019. 09.) Polyhexamethyleneguanidine phosphate-Induced cytotoxicity in liver cells is alleviated by tauroursodeoxycholic Acid (TUDCA) via a reduction in endoplasmic reticulum stress, Cells, 8(9). pii: E1023 *Co-first authors

25. Kwon D, Kwon JT, Lim YM, Shim I, Kim E, Lee DH, Yoon BI, Kim P, Kim HM (2019. 09.) Inhalation toxicity of benzalkonium chloride and triethylene glycol mixture in rats, Toxicology and Applied Pharmacology, 378:114609

24. Kwon D, Lim YM, Kwon JT, Shim I, Kim E, Lee DH, Yoon BI, Kim P, Kim HM (2019. 05.) Evaluation of pulmonary toxicity of benzalkonium chloride and triethylene glycol mixtures using in vitro and in vivo systems, Environmental Toxicology, 34(5):561-572

23. Kim SH*, Kwon D*, Kwak JH*, Lee SH, Lee YH, Yun J, Son TG, Jung YS (2018. 12.) Tunicamycin-induced ER stress is accompanied with oxidative stress via abrogation of sulfur amino acids metabolism in the liver, International Journal of Molecular Sciences, 19(12): pii: E4114
*Co-first authors

22. Kim YC, Na JD, Kwon D, Park JH (2018. 10.) Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in mice, Journal of Functional Foods, 49: 235-240

21. Kwon D, Kim HM, Kim EJ, Lim YM, Kim PJ, Choi KH, Kwon JT (2016) Acute pulmonary cytotoxicity and inflammation induced by combined exposure to didecyldimethylammonium chloride and ethylene glycol in rats, The Journal of Toxicological Sciences, 41(1): 17-24

20. Lee DH, Lee JS, Kwon JT, Kwon D, Kim EJ, Park SA, Lee HR, Kim HM, Choi JW, Lee WS (2015) Analytical methods for mixture of didecyldimethylammonium chloride and ethylene glycol in inhalation chamber, Journal of the Korean Society for Environmental Analysis, 18: 85-92

19. Ahn CW, Kwon D, Jun DS, Lee YM, Kim YC (2015) Enhancement of cysteine catabolism into taurine impacts glutathione homeostasis in rats challenged with ethanol, Amino Acids, 47: 1273-1277

18. Kwon D, Kim EJ, Kwon JT, Lee DH, Park SY, Kim HM, Kim PJ, Choi KH (2015) Ethylene glycol potentiated didecyldimethylammonium chloride toxicity in human bronchial epithelial cells, Molecular and Cellular Toxicology, 11:161-166

17. Oh JY, Kwak JH, Kwon D, Kim AY, Oh DS, Je NK, Lee JW, Jung YS (2014) Transformation of mouse liver cells by methylcholanthrene leads to phenotypic changes associated with epithelial-mesenchymal transition, Toxicological Research, 30: 1-6

16. Kim YC, Kwon D, Kim JH (2014) Alterations in the metabolomics of sulfur-containing substances in rat kidney by betaine, Amino Acids, 46: 963-968

15. Jung YS, Kim SJ, Kwon D, Ahn CW, Kim YS, Choi DW, Kim YC (2013) Alleviation of alcoholic liver injury by betaine involves an enhancement of antioxidant defense via regulation of sulfur amino acid metabolism, Food and Chemical Toxicology, 62: 292-298

14. Kwon D, Jung YS, Kim SJ, Kim YS, Choi DW, Kim YC (2013) Alterations in Sulfur Amino Acid Metabolism in Mice Treated with Silymarin: A Novel Mechanism of Its Action Involved in Enhancement of the Antioxidant Defense in Liver, Planta Medica, 79(12): 997-1002

13. Jung YS, Kim SJ, Kwon D, Jun DS, Kim YC (2013) Significance of alterations in the metabolomics of sulfur-containing amino acids during liver regeneration, Biochimie, 95(8): 1605-1610

12. Jung YS, Kim SJ, Kwon D, Kim YC (2012) Metabolomic analysis of sulfur-containing substances and polyamines in regenerating rat liver. Amino Acids, 42(6): 2095-2102

11. Kwon D, Kim SJ, Lee JW, Kim YC (2010) Comparison of hydroxyl radical, peroxyl radical, and peroxynitrite scavenging capacity of extracts and active components from selected medicinal plants, Toxicological Research, 26(4): 321？327

10. Kim SJ, Kwon D, Kim YS, Kim YC (2010) Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants, Archives of Pharmacal Research, 33(6): 867-873

9. Park HK, Kim SJ, Kwon D, Park JH, Kim YC (2010) Protective effect of quercetin against paraquat-induced lung injury in rats, Life Sciences, 87(5-6): 181-186

8. Kim SJ, Lee MY, Kwon D, Kim SY, Kim YC (2009) Alteration in metabolism and toxicity of acetaminophen upon repeated administration in rats, Journal of Pharmacological Sciences, 111(2): 175-181

7. Kim SJ, Lee JW, Jung YS, Kwon D, Park HK, Ryu CS, Kim SK, Oh GT, Kim YC (2009) Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice, Journal of Hepatology, 50(6): 1184-1191

6. Kwon D, Choi KH, Kim SJ, Choi DW, Kim YS, Kim YC (2009) Comparison of peroxyl radical scavenging capacity of commonly consumed beverages, Archives of Pharmacal Research, 32(2): 283-287

5. Choi DW, Kim SJ, Kwon D, Lee SY, Kim YC (2009) Taurine depletion by beta-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride, Advances in Experimental Medicine and Biology, 643: 305-311

4. Kwon D, Jung YS, Kim SJ, Park HK, Park JH, Kim YC (2009) Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats, The Journal of Nutrition, 139(1): 63-68

3. Kim SJ, Kwon D, Choi KH, Choi DW, Kim YC (2008) Impaired metabolomics of sulfur-containing substances in rats treated with carbon tetrachloride acutely, Toxicological Research, 24: 281-287

2. Jung YS, Kim SJ, Kwon D, Kim YC (2008) Comparison of the effects of buthioninesulfoximine and phorone on the metabolism of sulfur-containing amino acids in rat liver. Biochemical and Biophysical Research Communications, 368(4): 913-918

1. Kim SJ, Jung YS, Kwon D, Kim YC (2008) Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementation, Biochemical and Biophysical Research Communications, 368(4): 893-898

2009.02 College of Pharmacy, Seoul National University (B.S.)
2011.02 College of Pharmacy, Seoul National University (M.S.)
2014.08 College of Pharmacy, Seoul National University (Ph.D.)

Ha DK, Kim MJ, Han N, Kwak JH, Baek IH. Comparative Efficacy of Oral Calcitonin-Gene-Related Peptide Antagonists for the Treatment of Acute Migraine: Updated Meta-analysis. Clin Drug Investig. 2021 Feb;41(2):119-132.
Han N, Oh JM, Kim IW. Combination of Genome-Wide Polymorphisms and Copy Number Variations of Pharmacogenes in Koreans. J Pers Med. 2021 Jan 7;11(1):33.
Ngo TL, Lee CH, Han N, Back HM, Rhee SJ, Noh K, Yun HY, Kang W, Chae JW. Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans. Int J Mol Sci. 2020 Mar 9;21(5):1862.
Song YK, Han N, Burckart GJ, Oh JM. International Coherence of Pediatric Drug Labeling for Drug Safety: Comparison of Approved Labels in Korea and the United States. Clin Pharmacol Ther. 2020 Mar;107(3):530-540.
Han N, Oh JM, Kim IW. Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews. Sci Rep. 2020 Feb 20;10(1):3116.
Han A, Min SI, Ahn S, Min SK, Hong HJ, Han N, Kim YS, Ahn C, Ha J. Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: A randomized controlled trial. PLoS One. 2019 Nov 5;14(11):e0224595.
Kim MG, Huh S, Han N, Kim JH, Kim K, Lee E, Kim IW, Oh JM. Analysis of Issues and Future Trends Impacting Drug Safety in South Korea. Int J Environ Res Public Health. 2019 Sep 12;16(18):3368.
Rhew K, Han N, Oh JM. Impact of Safety Warning on Domperidone Prescribing for Geriatric Patients in South Korea: Analysis of National Insurance Claim Data. Int J Environ Res Public Health. 2019 Aug 20;16(16):2985.
Kim JH, Han N, Kim MG, Kim YW, Jang H, Yun HY, Yu MY, Kim IW, Kim YS, Oh JM. Model based development of tacrolimus dosing algorithm considering CYP3A5 genotypes and mycophenolate mofetil drug interaction in stable kidney transplant recipients. Sci Rep. 2019 Aug 13;9(1):11740.
Back HM, Lee JB, Han N, Goo S, Jung E, Kim J, Song B, An SH, Kim JT, Rhie SJ, Ree YS, Chae JW, Kim J, Yun HY. Application of Size and Maturation Functions to Population Pharmacokinetic Modeling of Pediatric Patients. Pharmaceutics. 2019 Jun 3;11(6):259.
Choi JE, Sa E, Ryu SH, Kim M, Kim KS, Han N, Cho Y, Oh JM. Improvement of the Multidisciplinary Team-based Critical Care Service for Patient in the Surgical Intensive Care Unit: A Qualitative Exploration of Healthcare Professional Needs. J Kor Soc Health-syst Pharm 2019;36:173-88.
Kim Y, Lee YS, Kim MG, Song YK, Kim Y, Jang H, Kim JH, Han N, Ji E, Kim IW, Oh JM. The effect of selective serotonin reuptake inhibitors on major adverse cardiovascular events: a meta-analysis of randomized-controlled studies in depression. Int Clin Psychopharmacol. 2019 Jan;34(1):9-17.
Han N, Jeong CR, Song YK, Yoon JH, Jang S, Lee EK, Shin HT, Lee YS, Shon HS, Ji E, Suh DC, Kim D, Oh JM. Development of Agenda for Pharmaceutical Care Service Research and Development using the Analytical Hierarchy Process. Korean J Clin Pharm 2019;29(1):45-55.
Huh S, Han N, Sohn M, Ryu J, Yang J, Oh JM. Formulation of the Scope and Key Questions of the Guideline Recommendations for Immunosuppressive Treatment in Kidney Transplantation. Korean J Clin Pharm 2019;29(1):18-24.
Sohn M, Kim MG, Han N, Kim IW, Gim J, Min SI, Song EY, Kim YS, Jung HS, Shin YK, Ha J, Oh JM. Whole exome sequencing for the identification of CYP3A7 variants associated with tacrolimus concentrations in kidney transplant patients. Sci Rep. 2018 Dec 24;8(1):18064.
Park HJ, Choi BY, Sohn M, Han N, Kim IW, Oh JM. Effects of Tumor Necrosis Factor-alpha Inhibitors on the Incidence of Tuberculosis. Korean J Clin Pharm 2018;28(4):333-41.
Kim IW, Kim JH, Han N, Kim S, Kim YS, Oh JM. Gene expression profiles for predicting antibody？mediated kidney allograft rejection: Analysis of GEO datasets. Int J Mol Med. 2018 Oct;42(4):2303-11.
Han N, Han SH, Chu H, Kim J, Rhew KY, Yoon JH, Je NK, Rhie SJ, Ji E, Lee E, Kim YS, Oh JM; DrugTEAM Study group. Service design oriented multidisciplinary collaborative team care service model development for resolving drug related problems. PLoS One. 2018 Sep 28;13(9):e0201705.
Kim IW, Kim JH, Han N, Kim S, Kim YS, Oh JM. Gene expression profiles for predicting antibody？mediated kidney allograft rejection: Analysis of GEO datasets. Int J Mol Med. 2018 Oct;42(4):2303-11.
Song YK, Kim JH, Choi B, Han N, Kim MG, Lee J, Lee H, Yoon J, Lee BJ, Oh JM. Strategic Priorities to Improve Effectiveness of Anti-smoking Interventions for the Korean Military: An Application of the Analytic Hierarchy Process. Mil Med. 2018 Jul 1;183(7-8):e223-e230.
Kwak CH, Sohn M, Han N, Cho YS, Kim YS, Oh JM. Effectiveness of febuxostat in patients with allopurinol-refractory hyperuricemic chronic kidney disease？. Int J Clin Pharmacol Ther. 2018 Jul;56(7):321-7.
Kang JE, Yu JM, Choi JH, Chung IM, Pyun WB, Kim SA, Lee EK, Han NY, Yoon JH, Oh JM, Rhie SJ. Development and clinical application of an evidence-based pharmaceutical care service algorithm in acute coronary syndrome. J Clin Pharm Ther. 2018 Jun;43(3):366-76.
Han N, Chae JW, Jeon J, Lee J, Back HM, Song B, Kwon KI, Kim SK, Yun HY. Prediction of Methionine and Homocysteine levels in Zucker diabetic fatty (ZDF) rats as a T2DM animal model after consumption of a Methionine-rich diet. Nutr Metab (Lond). 2018 Feb 10;15:14.
Jang HY, Song YK, Kim JH, Kim MG, Han N, Lee HY, Kim IW, Oh JM. Impact of depression on change in coronary heart disease risk status: the Korean Genome and Epidemiology Study (KoGES). Ther Clin Risk Manag. 2018 Jan 10;14:121-8.
Kim JH, Han N, Kim MG, Yun HY, Lee S, Bae E, Kim YS, Kim IW, Oh JM. Increased Exposure of Tacrolimus by Co-administered Mycophenolate Mofetil: Population Pharmacokinetic Analysis in Healthy Volunteers. Sci Rep. 2018 Jan 26;8(1):1687.
Back HM, Song B, Pradhan S, Chae JW, Han N, Kang W, Chang MJ, Zheng J, Kwon KI, Karlsson MO, Yun HY. A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption. BMC Pharmacol Toxicol. 2018 Jan 25;19(1):4.
Pradhan S, Song B, Lee J, Chae JW, Kim KI, Back HM, Han N, Kwon KI, Yun HY. Performance comparison of first-order conditional estimation with interaction and Bayesian estimation methods for estimating the population parameters and its distribution from data sets with a low number of subjects. BMC Med Res Methodol. 2017 Dec 1;17(1):154.
Back HM, Pradhan S, Yoon YR, Kang W, Chae JW, Han N, Miki N, Kwon KI, Kim SK, Yun HY. Population Pharmacokinetic Modeling and Simulation of Afloqualone to Predict Steady-state Exposure Levels. Int J Pharmacol 2018;14(2):276-84.
Han N, Han SH, Song YK, Kim MG, Kim YS, Kim IW, Oh JM. Statin therapy for preventing cardiovascular diseases in patients treated with tacrolimus after kidney transplantation. Ther Clin Risk Manag. 2017 Nov 21;13:1513-20.
Han N, Hong SH, Kim YS, Kim DK, Kim IW, Ji E, Oh JM. Effect of additive calcium administration on FGF23 levels in patients with mild chronic kidney disease treated with calcitriol: a randomized, open-labeled clinical trial. Ther Clin Risk Manag. 2017 Aug 14;13:999-1007.
Kang J, Rhew K, Oh JM, Han N, Lee IH, Je NK, Ji E, Lee E, Yoon JH, Rhie SJ. Satisfaction and expressed needs of pharmaceutical care services and challenges recognized by patients in South Korea. Patient Prefer Adherence. 2017 Aug 11;11:1381-8.
Han N, Song YK, Burckart GJ, Ji E, Kim IW, Oh JM. Regulation of Pharmacogene Expression by microRNA in The Cancer Genome Atlas (TCGA) Research Network. Biomol Ther (Seoul). 2017 Sep 1;25(5):482-9.
Kim KI, Jeong S, Han N, Oh JM, Oh KH, Kim IW. Identification of differentially expressed miRNAs associated with chronic kidney disease-mineral bone disorder. Front Med. 2017 Sep;11(3):378-85.
Han N, Lee JY, Gwak HS, Lee BK, Lee YS, Lee S, Yong CS, Kim JH, Oh JM. Selection of Tasks for Assessment of Pharmacy Clinical Performance in Koreanspd Pharmacist Licensure Examination: Results of an Expert Survey. Korean J Clin Pharm 2017;27(3):119-26.
Song YK, Han N, Kim MG, Chang HJ, Sohn HS, Ji E, Oh JM. A national pharmacoepidemiological study of antibiotic use in Korean paediatric outpatients. Arch Dis Child. 2017 Jul;102(7):660-6.
Jeong S, Sohn M, Kim JH, Ko M, Seo HW, Song YK, Choi B, Han N, Na HS, Lee JG, Kim IW, Oh JM, Lee E. Current globalization of drug interventional clinical trials: characteristics and associated factors, 2011-2013. Trials. 2017 Jun 21;18(1):288.
Kim KI, Suh HS, Kwak A, Kim S, Han N, Lee E, Oh JM. Development and validation of a modified Korean version of the Pharmacy Services Questionnaire (PSQ-K) for the quality assessment of community pharmacy services. PLoS One. 2017 Apr 25;12(4):e0174004.
Kim JH, Lee JY, Lee YS, Yong CS, Han N, Gwak HS, Oh J, Lee BK, Lee S. Attitudes to proposed assessment of pharmacy skills in Korean pharmacist licensure examination. J Educ Eval Health Prof. 2017 Mar 27;14:6.
Han N, Lee SM, Hong JY, Noh HJ, Ji E, Song YK, Song J, Kim IW, Kim YS, Oh JM. Clinical Outcomes of Multidisciplinary Team Care on the Regulation of Chronic Kidney Disease - Mineral and Bone Disorder (CKD-MBD) in Patients Undergoing Dialysis. Korean J Clin Pharm 2016;26(4):318-23.
Choi YJ, Ah YM, Kong J, Choi KH, Kim B, Han N, Yu YM, Oh JM, Shin WG, Lee HY, Lee JY. Implication of different initial beta blockers on treatment persistence: atenolol vs new-generation beta blocker, a population-based study. Cardiovasc Ther. 2016 Aug;34(4):268-75.
Jeong S, Kim IW, Oh KH, Han N, Joo KW, Kim HJ, Oh JM. Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients. Drug Des Devel Ther. 2016 Jul 8;10:2211-25.
Ah YM, Lee JY, Choi YJ, Kong J, Kim B, Choi KH, Han N, Yu YM, Oh JM, Shin WG, Lee HY. Influence of initial angiotensin receptor blockers on treatment persistence in uncomplicated hypertension: A nation-wide population-based study. Clin Exp Hypertens. 2016;38(3):325-30.
Kang JE, Han NY, Oh JM, Jin HK, Kim HA, Son IJ, Rhie SJ. Pharmacist-involved care for patients with heart failure and acute coronary syndrome: a systematic review with qualitative and quantitative meta-analysis. J Clin Pharm Ther. 2016 Apr;41(2):145-57.
Jeong S, Kim JH, Kim MG, Han N, Kim IW, Kim T, Oh JM. Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review. Onco Targets Ther. 2016 Feb 9;9:655-69.
Choi B, Kim MG, Han N, Kim T, Ji E, Park S, Kim IW, Oh JM. Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation. Pharmacogenomics. 2015;16(14):1585-94.
Kim MG, Kim IW, Choi B, Han N, Yun HY, Park S, Oh JM. Population pharmacokinetics of cyclosporine in hematopoietic stem cell transplant patients: consideration of genetic polymorphisms. Ann Pharmacother. 2015 Jun;49(6):622-30.
Kim MG, Han N, Lee EK, Kim T. Pegfilgrastim vs filgrastim in PBSC mobilization for autologous hematopoietic SCT: a systematic review and meta-analysis. Bone Marrow Transplant. 2015 Apr;50(4):523-30.
Han N, Yun HY, Kim IW, Oh YJ, Kim YS, Oh JM. Population pharmacogenetics pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients. Eur J Clin Pharmacol. 2014 Oct;70(10):1211-9.
Han N, Ha S, Yun HY, Kim MG, Min SI, Ha J, Lee JI, Oh JM, Kim IW. Population pharmacokinetic-pharmacogenetic model of tacrolimus in the early period after kidney transplantation. Basic Clin Pharmacol Toxicol. 2014 May;114(5):400-6.
Kim IW, Han N, Burckart GJ, Oh JM. Epigenetic changes in gene expression for drug-metabolizing enzymes and transporters. Pharmacotherapy. 2014 Feb;34(2):140-50.
Kim IW, Yun HY, Choi B, Han N, Kim MG, Park S, Oh JM. Population pharmacokinetics analysis of cyclophosphamide with genetic effects in patients undergoing hematopoietic stem cell transplantation. Eur J Clin Pharmacol. 2013 Aug;69(8):1543-51.
Han N, Yun HY, Hong JY, Kim IW, Ji E, Hong SH, Kim YS, Ha J, Shin WG, Oh JM. Prediction of the tacrolimus population pharmacokinetic parameters according to CYP3A5 genotype and clinical factors using NONMEM in adult kidney transplant recipients. Eur J Clin Pharmacol. 2013 Jan;69(1):53-63.
Kim IW, Noh H, Ji E, Han N, Hong SH, Ha J, Burckart GJ, Oh JM. Identification of factors affecting tacrolimus level and 5-year clinical outcome in kidney transplant patients. Basic Clin Pharmacol Toxicol. 2012 Oct;111(4):217-23.
Kim IW, Yun HY, Choi B, Han N, Park SY, Lee ES, Oh JM. ABCB1 C3435T genetic polymorphism on population pharmacokinetics of methotrexate after hematopoietic stem cell transplantation in Korean patients: a prospective analysis. Clin Ther. 2012 Aug;34(8):1816-26.
Kim IW, Moon YJ, Ji E, Kim KI, Han N, Kim SJ, Shin WG, Ha J, Yoon JH, Lee HS, Oh JM. Clinical and genetic factors affecting tacrolimus trough levels and drug-related outcomes in Korean kidney transplant recipients. Eur J Clin Pharmacol. 2012 May;68(5):657-69.

2014 Ph.D. College of Pharmacy, Seoul National University
2008 M.S. College of Pharmacy, Seoul National University
2006 B.S. College of Pharmacy, Seoul National University

2020.01-present Assistant Professor, College of Pharmacy, Jeju National University
2016-2019 Postdoctoral researcher, University of Wisconsin-Madison
2014-2016 Postdoctoral researcher, College of Pharmacy, Ajou University

1. Yoon WS‡, Seok SH‡, Won HS, Cho T, Lee SJ, Seo MD, “Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigB.” Int J Biol Macromol. Jun. 2019
2. Seok SH‡, Ma ZX‡, Feltenberger JB, Chen H, Chen H, Scarlett C, Lin Z, Satyshur KA, Cortopassi M, Jefcoate CR, Ge Y, Tang W, Bradfield CA, Xing Y‡, “Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR).” J Biol Chem. Feb. 2018
3. Kim JH, Won HS, Yoon, WS, Seok SH, Jung BJ, Lee SN, Sim DW, Seo MD, “Crystal Structure of Shigella flexneri SF173 Reveals A Dimeric Helical Bundle Conformation”, Crystals Feb. 2018
4. Kim HN‡, Seok SH‡, Lee YS, Won HS, Seo MD, “Crystal structure and functional characterization of SF216 from Shigella flexneri.” FEBS Lett. Nov. 2017
5. Seok SH‡, Lee W‡, Jiang L‡, Molugu K, Zheng A, Li Y, Park S, Bradfield CA, Xing Y, “Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex” Proc Natl Acad Sci U S A May 2017
6. Kim J‡, Seok SH‡, Hong E, Yoo TH, Seo MD, and Ryu Y, “Crystal structure and characterization of esterase Est25 mutants reveal improved enantioselectivity toward (S)-ketoprofen ethyl ester.” Appl Microbiol Biotechnol. Dec. 2016
7. Seo JH, Park JH, Lee EJ, Vo TT, Choi H, Kim JY, Jang JK, Wee HJ, Lee HS, Jang SH, Park ZY, Jeong J, Lee KJ, Seok SH, Park JY, Lee BJ, Lee MN, Oh GT, Kim KW, “ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.” Nat Commun. 6;7:12882, Oct. 2016
8. Kim JH, Sim DW, Park D, Jung TG, Lee S, Oh T, Ha JR, Seok SH, Seo MD, Kang HC, Kim YP, Won HS, “Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor.” Appl Microbiol Biotechnol. 100(24), 10521-10529., Dec. 2016
9. Kim HN‡, Seok SH‡, Chung KY, Won HS, Son WS and Seo MD, “Expression, purification and structural characterization of the type 1-specific ATP binding site of IP3 receptor (IP3R1-ATPA)” Process Biochemistry, 50(10), 1600？1606, Oct. 2015
10. Choi HJ‡, Seok SH‡, Kim YJ, Seo MD, and Kim YS, “Crystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation” Mol. Immunol. 65(2), 377-383., Mar. 2015
11. Kim HN, An JG, Lee YS, Seok SH, Yoo HS, and Seo MD, “Overexpression, purification, crystallization and preliminary X-ray crystallographic analysis of SF173 from Shigella flexneri” Acta Crystallogr. Sect. F 71, 54-56, Jan. 2015
12. Seok SH‡, Im H‡, Won HS‡, Seo MD, Lee YS, Yoon HJ, Cha MJ, Park JY and Lee BJ, “Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers”, Acta Crystallogr. Sect. D-Biol. Crystallogr. 70(6), 1726-1742, Jun. 2014
13. Seo MD‡, Seok SH‡, Im H, Kwon AR, Lee SJ, Kim HR, Cho Y, Park D, and Lee BJ, "Crystal structure of the dimerization domain of human filamin A." Proteins 75(1): 258-63, Apr. 2009
14. Seo MD, Park SJ, Seok SH, and Lee BJ, "Backbone 1H, 15N, and 13C Resonance Assignment and Secondary Structure Prediction of HP0495 from Helicobacter pylori" J. Biochem. Mol. Biol. 40(5), 839-843, Sep. 2007

Choi YJ, Park J, Choi H, Oh SJ, Park JH, Park M, Kim JW, Kim YG, Kim YC, Kim MJ, Kang KW (2023). PLM-101 is a novel and potent FLT3/RET inhibitor with less adverse effects in the treatment of acute myeloid leukemia. Biomed Pharmacother. Jun 29;165:115066.
Park M, Kang KW, Kim JW (2023). The role and application of transcriptional repressors in cancer treatment. Arch Pharm Res. 2023 Jan;46(1):1-17. doi: 10.1007/s12272-023-01427-4. Epub 2023 Jan 16.
Gupta N, Song H, Wu W, Ponce RK, Lin YK, Kim JW, Small EJ, Feng FY, Huang FW, Okimoto RA (2022). The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression. Elife, Nov 16;11:e77072.
Kim JW, Luck C, Wu W, Ponce RK, Lin YK, Gupta N, Okimoto RA (2022). Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer. Cell Rep, Oct 4;41(1):111443. doi: 10.1016/j.celrep.2022.111443.
Kim JW, Park M, Kim S, Lim SC, Kim HS, Kang KW (2021). Anti-metastatic effect of GV1001 on prostate cancer cells; roles of GnRHR-mediated Galphas-cAMP pathway and AR-YAP1 axis. Cell Biosci, 7;11(1):191.
Kim JW*, Ponce RK*, Okimoto RA (2021). Capicua in Human Cancer. Trends Cancer, 7(1):77-86. (*Co-first authors)
Park M, Kim JW, Kim KM, Kang S, Kim W, Kim JK, Cho Y, Lee H, Baek MC, Bae JH, Lee SH, Jeong SB, Lim SC, Jun DW, Cho SY, Kim Y, Choi YJ, Kang KW (2021). Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance. Cancer Res, 1;81(13):3539-3553.
An S, Kim G, Kim HJ, Ahn S, Kim HY, Ko H, Hyun YE, Nguyen M, Jeong J, Liu Z, Han J, Choi H, Yu J, Kim JW, Lee HW, Jacobson KA, Cho WJ, Kim YM, Kang KW, Noh M, Jeong LS (2020). Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators. J Med Chem, 24;63(24):16012-16027
Lin YK, Wu W, Ponce RK, Kim JW, Okimoto RA (2020). Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma. Proc Natl Acad Sci USA, 25;117(34):20776-20784.
Kim JW, Gautam JY, Kim JE, Kim JA, Kang KW (2019). Inhibition of tumor growth and angiogenesis of tamoxifen-resistant breast cancer cells by ruxolitinib, a selective JAK2 inhibitor. Oncology letters, 17(4):3981-3989.
Kim JW, Yadav DK, Kim SJ, Lee MY, Park JM, Kim BS, Kim MH, Park HG, Kang KW (2019). Anti-cancer effect of GV1001 for prostate cancer; function as a ligand of GnRHR. Endocrine Related Cancer, 26(2):147-162.
Thuy Phuong NT*, Kim JW* Kim JA, Jeon JS, Lee JY, Xu WJ, Yang JW, Kim SK, Kang KW (2017). Role of the CYP3A4-mediated 11,12-epoxyeicosatrienoic acid pathway in the development of tamoxifen-resistant breast cancer. Oncotarget, 18;8(41):71054-71069. (*Co-first authors)
Yang JW, Kim HS, Im JH, Kim JW, Jun DW, Lim SC, Lee K, Choi JM, Kim SK, Kang KW (2016). GPR119: a promising target for nonalcoholic fatty liver disease. FASEB J, 30(1):324-35.
수상경력
Feb. 28, 2018: Award for great paper, PharmNet, Seoul National University.
Nov. 16, 2017: Elsevier Award, ICEM-ACEM The 12th international conference & 5th Asian congress on environmental mutagens.
Jun. 26, 2015: Award for excellent poster presentation, The 7th international congress of Asian society of toxicology

2008. 3 - 2012. 2 College of Pharmacy, Kangwon National University (B.S.)
2012. 3 - 2018. 2 College of Pharmacy, Ajou University (Ph.D.)
Dissertation: Fattigation-platform self-assembled albumin nanoparticles in drug delivery
[Supervisor: Prof. Beom-Jin Lee]

2021. 9 - 2022. 7: Postdoctoral fellow, API, University of Alberta
2020. 9 - 2021. 8: Postdoctoral fellow, 아주대학교 약과학연구소
2019. 4 - 2020. 8: Postdoctoral fellow, DDIC, University of Alberta
2018. 3 - 2019. 3: Researcher, Korea United Pharm Inc

*Equally contributed
[44] Megumi Nishitani Yukuyama, Jieyu Zuo, Chulhun Park, Malaz Yousef, Mirla Anali Bazan Henostroza, Gabriel Lima Barros de Araujo, Nadia Araci Bou-Chacra, Raimar Lobenberg. Biphasic dissolution combined with modified cylinder method―A new promising method for dissolution test in drug-loaded nanoemulsions. International Journal of Pharmaceutics 632, 122554
[43] M Yousef, TS Le, J Zuo, C Park, NB Chacra, NM Davies, R Lobenberg. Sub-cellular sequestration of alkaline drugs in lysosomes: new insights for pharmaceutical development of lysosomal fluid. Research in Pharmaceutical Sciences 18 (1), 1-15
[42] M. Yousef, C. Park, T.S. Le, N.A. Bou-Chacra, N.M. Davies, R. Lobenberg, Simulated lymphatic fluid for in-vitro assessment in pharmaceutical development, Dissolution Technologies, 29 (2022) 86-93.
[41] C. Park, J.H. Lee, G. Jin, H.V. Ngo, J.B. Park, T.T.D. Tran, P.H.L. Tran, B.J. Lee, Release Kinetics of Hydroxypropyl Methylcellulose Governing Drug Release and Hydrodynamic Changes of Matrix Tablet, Curr Drug Deliv, 19 (2022) 520-533.
[40] J.-H. Lee*, C. Park*, I.-O. Song, B.-J. Lee, C.-Y. Kang, J.-B. Park, Investigation of Patient-Centric 3D-Printed Orodispersible Films Containing Amorphous Aripiprazole, Pharmaceuticals, 15 (2022) 895.
[39] G. Jin, H.V. Ngo, J. Wang, J.-H. Cui, Q.-R. Cao, C. Park, B.-J. Lee, Electrostatic molecular effect of differently charged surfactants on the solubilization capacity and physicochemical properties of salt-caged nanosuspensions containing pH-dependent and poorly water-soluble rebamipide, International Journal of Pharmaceutics, 619 (2022) 121686.
[38] G. Jin, H.V. Ngo, J. Wang, J.-H. Cui, Q.-R. Cao, C. Park, M. Jung, B.-J. Lee, Design and evaluation of in vivo bioavailability in beagle dogs of bilayer tablet consisting of immediate release nanosuspension and sustained release layers of rebamipide, International Journal of Pharmaceutics, 619 (2022) 121718.
[37] B. Hajjar, J. Zuo, C. Park, S. Azarmi, D.A. Silva, N.A. Bou-Chacra, R. Lobenberg, In Vitro Evaluation of a Foamable Microemulsion Towards an Improved Topical Delivery of Diclofenac Sodium, AAPS PharmSciTech, 23 (2022) 102.
[36] J.-y. Zuo, C. Park, M. Doschak, R. Lobenberg, Are the release characteristics of Erzhi pills in line with traditional Chinese medicine theory? A quantitative study, Journal of Integrative Medicine, 19 (2021) 50-55.
[35] J. Zuo, C. Park, J.Y.C. Kung, N.A. Bou-Chacra, M. Doschak, R. Lobenberg, Traditional Chinese Medicine “Pill”, an Ancient Dosage Form with Surprising Modern Pharmaceutical Characteristics, Pharmaceutical Research, 38 (2021) 199-211.
[34] Y. Yu, H.V. Ngo, G. Jin, P.H.L. Tran, T.T.D. Tran, C. Park, B.-J. Lee, Double-controlled release of poorly water-soluble paliperidone palmitate from self-assembled albumin-oleic acid nanoparticles in PLGA in situ forming implant, International journal of nanomedicine, 16 (2021) 2819.
[33] D.G. Won, G. Park, H.V. Ngo, G. Jin, C. Park, B.J. Lee, Evaluation of the impact of abuse deterring agents on the physicochemical factors of tramadol-loaded tablet and the definition of new abuse deterrent index, Int J Pharm, 605 (2021) 120726.
[32] C. Park, J. Zuo, V. Somayaji, B.-J. Lee, R. Lobenberg, Development of a novel cannabinoid-loaded microemulsion towards an improved stability and transdermal delivery, International Journal of Pharmaceutics, 604 (2021) 120766.
[31] J.-H. Lee*, C. Park*, K.-Y. Weon, C.-Y. Kang, B.-J. Lee, J.-B. Park, Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition, Pharmaceuticals, 14 (2021) 1255.
[30] J. Lee, H.V. Ngo, G. Jin, C. Park, J.-B. Park, P.H.L. Tran, T.T.D. Tran, V.H. Nguyen, B.-J. Lee, Effect of pH adjustment and ratio of oppositely charged polymers on the mechanistic performance and sustained release of volatile perfume in interpolyelectrolyte complex microcapsules, International Journal of Pharmaceutics, 604 (2021) 120672.
[29] H. Kim, D. Song, H.V. Ngo, G. Jin, C. Park, J.B. Park, B.J. Lee, Modulation of the clinically accessible gelation time using glucono-d-lactone and pyridoxal 5'-phosphate for long-acting alginate in situ forming gel injectable, Carbohydr Polym, 272 (2021) 118453.
[28] G. Jin, H.V. Ngo, J.-H. Cui, J. Wang, C. Park, B.-J. Lee, Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method, Pharmaceutics, 13 (2021) 662.
[27] H. Van Ngo, C. Park, T.T.D. Tran, B.-J. Lee, Mechanistic understanding of salt-induced drug encapsulation in nanosuspension via acid-base neutralization as a nanonization platform technology to enhance dissolution rate of pH-dependent poorly water-soluble drugs, European journal of pharmaceutics and biopharmaceutics, 154 (2020) 8-17.
[26] C. Park, N. Meghani, R. Loebenberg, J.-H. Cui, Q.-R. Cao, B.-J. Lee, Fatty acid chain length impacts nanonizing capacity of albumin-fatty acid nanomicelles: Enhanced physicochemical property and cellular delivery of poorly water-soluble drug, European Journal of Pharmaceutics and Biopharmaceutics, 152 (2020) 257-269.
[25] C. Park, N. Baek, R. Loebenberg, B.-J. Lee, Importance of the fatty acid chain length on in vitro and in vivo anticancer activity of fattigation-platform albumin nanoparticles in human colorectal cancer xenograft mice model, Journal of Controlled Release, 324 (2020) 55-68.
[24] B.-C. Oh, G. Jin, C. Park, J.-B. Park, B.-J. Lee, Preparation and evaluation of identifiable quick response (QR)-coded orodispersible films using 3D printer with directly feeding nozzle, International Journal of Pharmaceutics, 584 (2020) 119405.
[23] N.M. Meghani, H. Amin, C. Park, J.-H. Cui, Q.-R. Cao, K.H. Choi, B.-J. Lee, Combinatory interpretation of protein corona and shear stress for active cancer targeting of bioorthogonally clickable gelatin-oleic nanoparticles, Materials Science and Engineering: C, 111 (2020) 110760.
[22] D. Kim, C. Park, N.M. Meghani, T.T.D. Tran, P.H.L. Tran, J.-B. Park, B.-J. Lee, Utilization of a fattigation platform gelatin-oleic acid sodium salt conjugate as a novel solubilizing adjuvant for poorly water-soluble drugs via self-assembly and nanonization, International journal of pharmaceutics, 575 (2020) 118892.
[21] T. Kang, C. Park, N. Meghani, T.T.D. Tran, P.H.L. Tran, B.-J. Lee, Shear stress-dependent targeting efficiency using self-assembled gelatin-oleic nanoparticles in a biomimetic microfluidic system, Pharmaceutics, 12 (2020) 555.
[20] C. Park, N.M. Meghani, Y. Shin, E. Oh, J.-B. Park, J.-H. Cui, Q.-R. Cao, T.T.-D. Tran, P.H.-L. Tran, B.-J. Lee, Investigation of crystallization and salt formation of poorly water-soluble telmisartan for enhanced solubility, Pharmaceutics, 11 (2019) 102.
[19] C. Park, N. Meghani, H. Amin, P.H.L. Tran, T.T.D. Tran, V.H. Nguyen, B.-J. Lee, The roles of short and long chain fatty acids on physicochemical properties and improved cancer targeting of albumin-based fattigation-platform nanoparticles containing doxorubicin, International journal of pharmaceutics, 564 (2019) 124-135.
[18] K.-Y. Nam, S.M. Cho, Y.-W. Choi, C. Park, N.M. Meghani, J.-B. Park, B.-J. Lee, Double controlled release of highly insoluble cilostazol using surfactant-driven pH dependent and pH-independent polymeric blends and in vivo bioavailability in beagle dogs, International Journal of Pharmaceutics, 558 (2019) 284-290.
[17] J.-B. Park*, C. Park*, Z.Z. Piao, H.H. Amin, N.M. Meghani, P.H.L. Tran, T.T.D. Tran, J.-H. Cui, Q.-R. Cao, E. Oh, pH-independent controlled release tablets containing nanonizing valsartan solid dispersions for less variable bioavailability in humans, Journal of Drug Delivery Science and Technology, 46 (2018) 365-377.
[16] N.M. Meghani, H.H. Amin, T.T.D. Tran, P.H.L. Tran, C. Park, B.-J. Lee, Modulation of serum albumin protein corona for exploring cellular behaviors of fattigation-platform nanoparticles, Colloids and Surfaces B: Biointerfaces, 170 (2018) 179-186.
[15] N.M. Meghani, H.H. Amin, C. Park, J.-B. Park, J.-H. Cui, Q.-R. Cao, B.-J. Lee, Design and evaluation of clickable gelatin-oleic nanoparticles using fattigation-platform for cancer therapy, International Journal of Pharmaceutics, 545 (2018) 101-112.
[14] K.-H. Lee*, C. Park*, G. Oh, J.-B. Park, B.-J. Lee, New blends of hydroxypropylmethylcellulose and Gelucire 44/14: physical property and controlled release of drugs with different solubility, Journal of Pharmaceutical Investigation, 48 (2018) 313-321.
[13] N. Baek, G.-H. Oh, C. Park, T.T.T. Tran, Y.J. Park, E. Oh, H. Le, T.T.D. Tran, J.-B. Park, B.-J. Lee, Reprecipitation of poorly water-soluble cilostazol crystals using adsorbing carriers for enhanced dissolution and physicochemical modification, Journal of drug delivery science and technology, 43 (2018) 477-486.
[12] C. Park, N.M. Meghani, H.H. Amin, V.H. Nguyen, B.-J. Lee, Patient-centered drug delivery and its potential applications for unmet medical needs, Therapeutic delivery, 8 (2017) 775-790.
[11] D. Luo, J.H. Kim, C. Park, E. Oh, J.-B. Park, J.-H. Cui, Q.-R. Cao, B.-J. Lee, Design of fixed dose combination and physicochemical characterization of enteric-coated bilayer tablet with circadian rhythmic variations containing telmisartan and pravastatin sodium, International Journal of Pharmaceutics, 523 (2017) 343-356.
[10] W.-H. Kang, H. Van Nguyen, C. Park, Y.-W. Choi, B.-J. Lee, Modulation of microenvironmental pH for dual release and reduced in vivo gastrointestinal bleeding of aceclofenac using hydroxypropyl methylcellulose-based bilayered matrix tablet, European Journal of Pharmaceutical Sciences, 102 (2017) 85-93.
[9] T. Kang, T.T.-T. Tran, C. Park, B.-J. Lee, Biomimetic shear stress and nanoparticulate drug delivery, Journal of Pharmaceutical Investigation, 47 (2017) 133-139.
[8] H.H. Amin, N.M. Meghani, C. Park, T.T.-D. Tran, P.H.-L. Tran, B.-J. Lee, Fattigation-platform nanoparticles using apo-transferrin stearic acid as a core for receptor-oriented cancer targeting, Colloids and Surfaces B: Biointerfaces, 159 (2017) 571-579.
[7] H. Van Nguyen*, C. Park*, E. Oh, B.-J. Lee, Improving the dissolution rate of a poorly water-soluble drug via adsorption onto pharmaceutical diluents, Journal of Drug Delivery Science and Technology, 35 (2016) 146-154.
[6] T. Kang, C. Park, B.-J. Lee, Investigation of biomimetic shear stress on cellular uptake and mechanism of polystyrene nanoparticles in various cancer cell lines, Archives of pharmacal research, 39 (2016) 1663-1670.
[5] T. Kang, C. Park, J.-S. Choi, J.-H. Cui, B.-J. Lee, Effects of shear stress on the cellular distribution of polystyrene nanoparticles in a biomimetic microfluidic system, Journal of Drug Delivery Science and Technology, 31 (2016) 130-136.
[4] T. Kang, Y. Cho, C. Park, S.-D. Kim, E. Oh, J.-H. Cui, Q.-R. Cao, B.-J. Lee, Effect of biomimetic shear stress on intracellular uptake and cell-killing efficiency of doxorubicin in a free and liposomal formulation, International journal of pharmaceutics, 510 (2016) 42-47.
[3] T.-H. Tran*, C. Park*, T. Kang, Y.-J. Park, E. Oh, B.-J. Lee, Micromeritic properties and instrumental analysis of physical mixtures and solid dispersions with adsorbent containing losartan: Comparison of dissolution-differentiating factors, Powder Technology, 272 (2015) 269-275.
[2] C. Park, C.L.-N. Vo, T. Kang, E. Oh, B.-J. Lee, New method and characterization of self-assembled gelatin-oleic nanoparticles using a desolvation method via carbodiimide/N-hydroxysuccinimide (EDC/NHS) reaction, European Journal of Pharmaceutics and Biopharmaceutics, 89 (2015) 365-373.
[1] C.L.-N. Vo, C. Park, B.-J. Lee, Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs, European journal of pharmaceutics and biopharmaceutics, 85 (2013) 799-813.

Patent & Patent Applications

[5] Beom-Jin Lee.; Chulhun Park.; Luo Daoqi.; “Bilayered composite formulation comprising angiotensin recepter blocker and HMG-CoA reductase inhibitor and preparation method thereof)\” Korea Patent No. 1018830910000 (2018.07.23)
[4] Beom-Jin Lee.; Chulhun Park.; Hien Van Nguyen.; “Solid Dispersions Comprising Proton Pump Inhibitor, Method for Preparing the Same and Orally Disintegrating Tablets Comprising the Same)\” Korea Patent No. 1018491250000 (2018.03.19)
[3] Beom-Jin Lee.; Chulhun Park.; Hien Van Nguyen.; “Proton pump inhibitor dispersion and pharmaceutical composition comprising the same” Korea Patent No. 1018416620000 (2018.03.19)
[2] Beom-Jin Lee.; Chulhun Park.; Seungho Jung.; “Preparation method of coating solution comprising rice starch and coating solution prepared thereby method” Korea Patent No. 1016908640000 (2016.12.22)
[1] Beom-Jin Lee.; Chulhun Park.; Hien Van Nguyen.; “Preparation method of oral tablets comprising Celecoxib” Korea Patent No. 1016171190000 (2016.04.25)

12. Karapetian K‡, Jeon SM‡, Kwon J, Suh Y. Supervised Relation Extraction Between Suicide-Related Entities and Drugs: Development and Usability Study of an Annotated PubMed Corpus. J Med Internet Res 2023;25:e41100. doi: 10.2196/41100. PMID: 36884281‡co-first authors
11. Jeon SM‡, Cho J‡, Lee DY, Kwon JW. Comparison of prediction methods for treatment continuation of antipsychotics in children and adolescents with schizophrenia. Evid Based Ment Health. 25(e1), e26-e33. doi:10.1136/ebmental-2021-300404‡co-first authors
10. Jeon SM, Park H, Park S, Chung US, Kwon J. Association of Treatment With Antipsychotics, Antidepressants, or Both With Movement Disorders and Seizures Among Children and Adolescents With Depression in Korea. JAMA Netw Open. 2022;5(4):e227074. doi:10.1001/jamanetworkopen.2022.7074
9. Kwon Y, Kwon JW, Ha J, … Jeon SM et al. Remission of type 2 diabetes after gastrectomy for gastric cancer: diabetes prediction score. Gastric Cancer. Jan 2022;25(1):265-274. doi:10.1007/s10120-021-01216-2
8. Park HY, Yang HJ, Jeon SM, Lee IH, Kwon JW. Survival and medical costs of melanoma patients with subsequent cancer diagnoses: A South Korean population-based retrospective cohort study. Asia Pac J Clin Oncol. Oct 2022;18(5):e211-e219. doi:10.1111/ajco.13582
7. Jeon SM‡, Park S‡, Kim D, Kwon JW. Risk of seizures associated with antipsychotic treatment in pediatrics with psychiatric disorders: a nested case-control study in Korea. Eur Child Adolesc Psychiatry. Mar 2021;30(3):391-399. doi:10.1007/s00787-020-01525-4
6. Jeon SM ‡, Park S‡, Kwon S, Kwon JW. Association Between Antipsychotic Treatment and Neurological Adverse Events in Pediatric Patients: A Population-Based Cohort Study in Korea. Frontiers in psychiatry. May 26 2021;12doi:ARTN 668704 10.3389/fpsyt.2021.668704 ‡co-first authors
5. Park HY, Hwang J, Kim DH, Jeon SM, Choi SH, Kwon JW. Lifetime survival and medical costs of lung cancer: a semi-parametric estimation from South Korea. BMC Cancer. Sep 3 2020;20(1) doi:ARTN 846 10.1186/s12885-020-07353-8
4. An SN, Park HY, Oh SH,… Jeon SM et al. Cost-effectiveness of Bariatric Surgery for People with Morbid Obesity in South Korea. Obesity surgery. Jan 2020;30(1):256-266. doi:10.1007/s11695-019-04122-w
3. Jeon SM‡, Park S‡, Rhie SJ, Kwon JW. Prescribing patterns of polypharmacy in Korean pediatric patients. PLOS ONE. 2019;14(10): e0222781. Published 2019 Oct 1. doi:10.1371/journal.pone. 0222781 ‡co-first authors
2. Park S‡, Jeon SM‡, Jung SY, Hwang J, Kwon JW. Effect of late-life weight change on dementia incidence: a 10-year cohort study using claim data in Korea. BMJ Open. 2019;9(5):e021739. Published 2019 May 20. doi:10.1136/bmjopen-2018-021739 ‡co-first authors
1. Jeon SM‡, Kwon JW‡, Choi SH, Park HY (2019) Economic burden of lung cancer: A retrospective cohort study in South Korea, 2002-2015. PLOS ONE 14(2): e0212878. https://doi.org/10.1371/journal.pone.0212878 ‡co-first authors