Cho, Moon-Jae Professor

| Career and thesis | |
|---|---|
| Education | Ph. D. 1995
University of Oklahoma Health Sciences Center (Oklahoma City, Oklahoma), Department of Biochemistry and Molecular Biology M.S. 1988 Seoul National University (Suwon, Korea) Department of Agricultural Chemistry B.S. 1986 Seoul National University (Suwon,Korea) Department of Agricultural Chemistry |
| Major career | Oct. 2009 ? present : Professor at the Jeju National University Medical School.
Mar. 2016 ? present : President of Institute of Medical Science, Jeju National University Oct. 2006 - Sep. 2010 : Present Jeju national university research instrument center director Aug. 2005 - Jul. 2006 : Exchange professor at the UC Davis Sep. 1998 ? Sep. 2009 : Assistant and Associate professor at the Jeju National University Medical School. Mar. 1997-Sep. 1998 : Research Associate at the Department of pathology at University of Michigan and Howard Hughes Medical Institute Aug. 1995-Feb.1997 : Post-doctoral fellow at University of Oklahoma Medical School, Department of Biochemistry Sep. 1990-Jun. 1992 : Research Assistant at the University of Georgia, Athens, Georgia under the direction of Dr. Richard D. Cummings, Dept. of Biochemistry. Mar. 1986-Feb. 1988 : Research Assistant, Lab. of biophysical chemistry at Seoul National University (Suwon), Department of Agricultural Chemistry |
| main paper | 1. Yoon-Suk Kang, Young-Mee Kim, Kyung-Il Park, Somi Kim Cho, Kwang-Sik Choi, Moonjae Cho. Analysis of EST and lectin expressions in hemocytes of Manila clams (Ruditapes philippinarum) (Bivalvia: Mollusca) infected with Perkinsus olseni, Developmental & Comparative Immunology, Vol. 30(12) 1119-1131 (2006) Epub 2006 Apr 25.
2. Young Mee Kim, Kyung-Il Park, Kwang-Sik Choi, Richard A. Alvarez, Richard D. Cummings, and Moonjae Cho. Lectin from the Manila Clam Ruditapes philippinarumis induced upon infection with the protozoan parasite Perkinsus olseni. The Journal of Biological Chemistry Vol. 281(37) 26854-26864 (2006) Epub 2006 Jun 19. 3. Kim YB, Choi S, Choi MC, Oh MA, Lee SA, Cho M, Mizuno K, Kim SH, Lee JW. Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex. J Biol Chem. 283(15):10089-96 2008 Apr 11. Epub 2008 Feb 5. 4. Kim JY, Kim YM, Cho SK, Choi KS, Cho M. Noble tandem-repeat galectin of Manila clam Ruditapes philippinarum is induced upon infection with the protozoan parasite Perkinsus olseni. Dev Comp Immunol. 2008;32(10):1131-41. Epub 2008 Apr 7. 5. Y.-S. Kang, K-S. Choi, Y.B.Chung, S.Kim amd M.Cho/ Protease associatedwith lectin produced by perkinsus olseni infected Manila clams (Ruditapes philippinarum) Bull. Eur. Ass. Fish. Pathol., 28(3) 2008 89-96 2008/08/22 6. Kim JY, Adhya M, Cho SK, Choi KS, Cho M. Characterization, tissue expression, and immunohistochemical localization of MCL3, a C-type lectin produced by Perkinsus olseni-infected Manila clams (Ruditapes philippinarum). Fish Shellfish Immunol. 2008 Nov;25(5):598-603. Epub 2008 Aug 5. 7. Hee-Kyoung Lim, Jeong Yong Moon, Hana Kim, Moonjae Cho and Somi Kim Cho. Induction of apoptosis in U937 human leukemia cells by the hexane fraction of an extract of immature Citrus grandis Osbeck fruits Food Chemistry.accepted 2008/10/31 (2009) 114 1245-1250 8. Sean R. Stowell, Moonjae Cho, Christa L. Feasley, Conne M. Arthur, Xuezheng Song, Jennifer K. colucci, Sougata Karmakar, Padmaja Mehta, Marcelo Dias-Baruffi, Rodger P. McEver, Richard. Cummings. Ligand reduces galcetin-1 sensitivity to oxidative inactivation by enhancing dimmer formation. JBC 2008/12/22 2009 02 20 284(4) 4989-4999 9. Sin-Ae Lee, Hyung Won Ryu, Young Mee Kim, Suyong Choi, Mi Ji Lee, Tae Kyounh Kwak, Hyeon Jung Kim, Moonjae Cho, Ki Hun Park, Jung Weon Lee. Blockade of four-transmembrane L six family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. Hepatology 2008/12/8 2009 49 1316-1325 10. Yoon-Suk Kang, Yukyung Lee, Somi K. Cho, Keun-Hwa Lee, Bum-Joon Kim, Minkyun Kim,Yoongho Lim & Moonjae Cho. Antibacterial activity of a disaccharide isolated from Streptomyces sp. strain JJ45 against Xanthomonas sp. FEMS Microbiol Lett 294 (2009) 119125. 2009/03/18 11. Lee SA, Kim TY, Kwak TK, Kim H, Kim S, Lee HJ, Kim SH, Park KH, Kim HJ, Cho M, Lee JW. Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis. J Cell Biochem. 2010 Sep 1;111(1):59-66. doi: 10.1002/jcb.22662. 12. Lee SA, Ryu HW, Kim YM, Choi S, Lee MJ, Kwak TK, Kim HJ, Cho M, Park KH, Lee JW. Blockade of four-transmembrane L six family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. Hepatology. 2009 Apr;49(4):1316-25. doi: 10.1002/hep.22777. 13. Dias-Baruffi M, Stowell SR, Song SC, Arthur CM, Cho M, Rodrigues LC, Montes MA, Rossi MA, James JA, McEver RP, Cummings RD. Differential expression of immunomodulatory galectin-1 in peripheral leukocytes and adult tissues and its cytosolic organization in striated muscle. Glycobiology. 2010 May;20(5):507-20. doi: 10.1093/glycob/cwp203. Epub 2010 Jan 5. 14. Hana Kim, Jeong Yong Moon, Hyeonji Kim, Dong-Sun Lee, Moonjae Cho, Hyung-Kyoon Choi, Young Suk Kim, Ashik Mosaddik, Somi Kim Cho. Antioxidant and antiproliferative activities of mango(Mangifera ndica L.) flesh and peel. Food Chemistry 2010 Jul; 121(2):429?436 doi: 10.1016/j.foodchem.2009.12.060 15. Park KI, Yang HS, Kang HS, Cho M, Park KJ, Choi KS. Isolation and identification of Perkinsus olseni from feces and marine sediment using immunological and molecular techniques. J Invertebr Pathol. 2010 Nov;105(3):261-9. doi: 10.1016/j.jip.2010.07.006. Epub 2010 Aug 4. 16. Kim JY, Nam JK, Lee SA, Lee MS, Cho SK, Park ZY, Lee JW, Cho M. Proteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression. J Cell Biochem. 2011 Mar;112(3):782-92. doi: 10.1002/jcb.22954. 17. Jeong Yong Moon, Ashik Mosaddik, Hana Kim, Moonjae Cho, Hyung-Kyoon Choi, Young Suk Kim, Somi Kim Cho. The chloroform fraction of guava (Psidium cattleianum sabine) leaf extract inhibits human gastric cancer cell proliferation via induction of apoptosis. Food Chemistry 2011 Mar;125(2):369?375 http://dx.doi.org/10.1016/j.foodchem.2010.09.007 18. Yang CH, Cho M. Hepatitis B virus X gene differentially modulates cell cycle progression and apoptotic protein expression in hepatocyte versus hepatoma cell lines. J Viral Hepat. 2013 Jan;20(1):50-8. doi: 10.1111/j.1365-2893.2012.01625.x. Epub 2012 May 24 19. Cho M, Yoon H, Park M, Kim YH, Lim Y. Flavonoids promoting HaCaT migration: I. Hologram quantitative structure-activity relationships. Phytomedicine. 2014 Mar 15;21(4):560-9. doi: 10.1016/j.phymed.2013.10.006. Epub 2013 Nov 16. 20. Moon JY, Cho M, Ahn KS, Cho SK. Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells. Nutr Cancer. 2013;65(2):286-95. doi: 10.1080/01635581.2013.756529. 21. Tran TA, Ahn KS, Song YW, Moon JY, Cho M, Lim Y, Cho SK. Mechanism of 2',3'-dimethoxyflavanone-induced apoptosis in breast cancer stem cells: Role of ubiquitination of caspase-8 and LC3. Arch Biochem Biophys. 2014 Nov 15;562:92-102. doi: 10.1016/j.abb.2014.08.001. Epub 2014 Aug 14. 22. Bui NT, Ho MT, Kim YM, Lim Y, Cho M. Flavonoids promoting HaCaT migration: II. Molecular mechanism of 4′,6,7-trimethoxyisoflavone via NOX2 activation. Phytomedicine. 2014 Mar 15;21(4):570-7. doi: 10.1016/j.phymed.2013.10.010. Epub 2013 Dec 30 23. Yang CH, Cho M. Hepatitis B virus X gene differentially modulates cell cycle progression and apoptotic protein expression in hepatocyte versus hepatoma cell lines. J Viral Hepat. 2013 Jan;20(1):50-8. doi: 10.1111/j.1365-2893.2012.01625.x. Epub 2012 May 24. 24. Kim YM, Cho M. Activation of NADPH oxidase subunit NCF4 induces ROS-mediated EMT signaling in HeLa cells. Cell Signal. 2014 Apr;26(4):784-96. doi: 10.1016/j.cellsig.2013.12.005. Epub 2013 Dec 27. 25. Ho MT, Kang HS, Huh JS, Kim YM, Lim Y, Cho M. Effects of the Novel Compound DK223 ([1E,2E-1,2-Bis(6-methoxy-2H-chromen-3-yl)methylene]hydrazine) on Migration and Proliferation of Human Keratinocytes and Primary Dermal Fibroblasts. Int J Mol Sci. 2014 Jul 23;15(7):13091-110. doi: 10.3390/ijms150713091. 26. Kim YM, Huh JS, Lim Y, Cho M. Soy isoflavone glycitin (4'-hydroxy-6-methoxyisoflavone-7-D-glucoside) promotes human dermal fibroblast cell proliferation and migration via TGF-β signaling. Phytother Res. 2015 May;29(5):757-69. doi: 10.1002/ptr.5313. Epub 2015 Mar 11. 27. Sophors P, Kim YM, Seo GY, Huh JS, Lim Y, Koh DS4, Cho M. A synthetic isoflavone, DCMF, promotes human keratinocyte migration by activating Src,FAK signaling pathway. Biochem Biophys Res Commun. 2016 Apr 1;472(2):332-8. doi: 10.1016/j.bbrc.2016.02.106. Epub 2016 Feb 26. 28. Han S, Bui NT, Ho MT, Kim YM, Cho M, Shin DB. Dexamethasone inhibits tgf-b1-induced cell migration by regulating the ERK and AKT pathways in human colon cancer cells via CYR61. Cancer Res Treat. 2016 Jul;48(3):1141-53. doi: 10.4143/crt.2015.209. Epub 2015 Dec 15. |

| Career and thesis | |
|---|---|
| Education | 1990-1993 College of Pharmacy, Seoul National University Ph.D.
1988-1990 College of Pharmacy, Seoul National University Master 1982-1986 College of Pharmacy, Ducksung Woman's University, Bachelor |
| Major career | 2002-present Professor at College of Medicine, Jeju National University
1998-2002 BK 21 professor at Seoul National University 1996-1998 Poster-doctor at Louis Pasteur University(France) 1992-1996 Senior scientist at cancer institute of Seoul National University |
| main paper | -Zhang R, Piao MJ, Kim KC, Kim AD, Choi JY, Choi J, Hyun JW. Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis. Int J Biochem Cell Biol. 44(1);224-232 (2012)
-Piao MJ, Zhang R, Lee NH, Hyun JW. Protective effect of triphlorethol-A against ultraviolet B-mediated damage of human keratinocytes. J Photochem Photobiol B. 106 (1): 74-80 (2012) -Kang KA, Zhang R, Kim GY, Bae SC, Hyun JW. Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3. Tumour Biology, 33:403-412 (2012) |